Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main properties of satellite cells and other myogenic progenitors as well as recent efforts to obtain myogenic cells from pluripotent stem cells for patient-tailored cell therapy. Clinical trials utilizing these cells to treat muscular dystrophies, heart failure, and stress urinary incontinence are also briefly outlined.

Adult muscle stem cells, or satellite cells have essential roles in homeostasis and regeneration of skeletal muscles. Satellite cells are located within a niche that includes myofibers and extracellular matrix. The function of specific extracellular matrix molecules in regulating SCs is poorly understood. Here, we show that the extracellular matrix protein collagen VI is a key component of the satellite cell niche. Lack of collagen VI in Col6a1^–/– mice causes impaired muscle regeneration and reduced satellite cell self-renewal capability after injury. Collagen VI null muscles display significant decrease of stiffness, which is able to compromise the in vitro and in vivo activity of wild-type satellite cells. When collagen VI is reinstated in vivo by grafting wild-type fibroblasts, the biomechanical properties of Col6a1^–/– muscles are ameliorated and satellite cell defects rescued. Our findings establish a critical role for an extracellular matrix molecule in satellite cell self-renewal and open new venues for therapies of collagen VI-related muscle diseases.

Light-emitting diodes (LEDs), which will be increasingly used in lighting technology, will also allow for distribution of broadband optical wireless signals. Visible-light communication (VLC) using white LEDs offers several advantages over the RF-based wireless systems, i.e., license-free spectrum, low power consumption, and higher privacy. Mostly, optical wireless can provide much higher data rates. In this paper, we demonstrate a VLC system based on a white LED for indoor broadband wireless access. After investigating the nonlinear effects of the LED and the power amplifier, a data rate of 1 Gb/s has been achieved at the standard illuminance level, by using an optimized discrete multitone modulation technique and adaptive bit- and power-loading algorithms. The bit-error ratio of the received data was $1.5\cdot 10^{-3}$, which is within the limit of common forward error correction (FEC) coding. These results twice the highest capacity that had been previously obtained.

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