The climatic conditions in Kuwait necessitate almost all buildings to be centrally air-conditioned with the latest HVAC system to provide the comfortable thermal environment for occupants. Mosques are used five times a day for a maximum time span of about half an hour or less for regular prayers. The study period was selected in the month of November when the ambient temperatures are moderate and cooling or heating is not required. The influence of natural draft through doors and other indoor/outdoor air exchange sites was examined for indoor air quality, degree of comfort, and different sorts of satisfaction during prayers. The indoor air quality is of major concern for mental, spiritual, and social satisfaction of the chaotic lifestyle of the present-day community. A weeklong study was conducted to measure temperature, humidity, carbon dioxide, and over 70 volatile organic compounds indoors and in the ambient air in the vicinity of the selected mosque.