Potentiometry is one of the most important electrochemical methods and potentiometric based sensors have been extensively studied by researchers for many years. The fact that potentiometric sensors have several advantages over other analytical devices is another reason for intensive research on the topic. In this area, hundreds of different sensors have been developed till today and introduced into the literature. The successful use of the developed sensors, particularly in real sample analysis, has made potentiometric sensors the center of attention. In this review, we highlight the studies which have been successfully applied to the developed drug samples and also to many real samples, with high recovery rates.

Potentiometry is extensively studied by researchers as one of the electrochemical methods due to its multiple advantages. Until today, thousands of potentiometric sensors have been developed and applied successfully in many fields such as medicine, environmental monitoring, agriculture, industry and pharmaceutical sciences. Clinical drug analyses and determination of drugs in biological samples are highly important from a medical point of view. These analyses are carried out using various analytical devices including potentiometric sensors. These potentiometric sensors are superior to other devices in terms of several performance parameters, and thus present a good alternative for researchers. Using potentiometric sensors, very successful results in the identification of drug molecules in body fluids have been obtained and reported in the literature up to now. In this study, we review potentiometry-based sensors developed for the determination of drug molecules in various biological samples such as blood serum and urine, and touch upon their performance features in these applications.