In this work, an experimental and numerical analysis of a lattice structure for energy absorption was carried out. The goal was to identify the most influencing parameters of the unit cell on the crushing performances of the structure, thus guiding the design of energy absorbers. Two full factorial plans of compression tests on cubic specimens of carbon nylon produced by fused deposition modeling (FDM) were performed. The factors were the beam diameter and the number of unit cells. In the first factorial plan, the specimen volume is constant and the dimensions of the unit cell are varied, while the second factorial plan assumes a constant size of the unit cell and the volume changes in accordance with their number. The results showed that the specific energy absorption increases with the diameter of the beam and decreases with the size of the unit cell. Based on these results, a crash absorber for the segment C vehicle was designed and compared with the standard component of the vehicle made of steel. In addition to a mass reduction of 25%, the improved crushing performances of the lattice structure are shown by the very smooth force-displacement curve with limited peaks and valleys.