Bisacurone is a sesquiterpenoid constituent of Curcuma longa that has received considerably less attention than curcuminoids despite emerging evidence of its biological activity. In this study, the anti-inflammatory potential of bisacurone isolated from the Ryudai gold variety of Curcuma longa was evaluated using an integrated in vivo and in silico approach. Acute inflammation was assessed in rats using a carrageenan-induced paw edema model, supported by histopathological examination of paw tissues. Bisacurone significantly reduced paw edema during the peak inflammatory phase and markedly attenuated dermal thickening and inflammatory cell infiltration, indicating effective suppression of acute inflammatory responses. The effects of bisacurone were comparable to that of indomethacin. To elucidate the underlying molecular basis, density functional theory calculations, molecular docking, molecular dynamics simulations, and pharmacokinetic and toxicity predictions were performed. In silico analyses revealed favorable electronic properties, drug-likeness, and stable interactions of bisacurone with key inflammatory regulators, particularly IKKβ and COX-1, along with moderate interactions with MAPKs and iNOS. Molecular dynamics simulations confirmed the stability of the protein–ligand complexes. Collectively, these findings demonstrate that bisacurone exerts anti-inflammatory effects through multi-target modulation of inflammatory signaling pathways and highlight its potential as a bioactive functional food component and a lead compound for anti-inflammatory drug development.

We report the draft genome of Staphylococcus haemolyticus AIL_BAU_sh26 from a circulating banknote in Bangladesh. The 2.48 Mb genome (32.6% GC; 79 contigs; N50 89,821 bp) encodes 2,487 coding sequences, 34 tRNAs, and 3 rRNAs. Multiple antimicrobial resistance determinants, including mecA , and a plasmid replicon were identified, underscoring the public health relevance of environmental staphylococcal genomic surveillance.

Purpose: The Bengal slow loris (Nycticebus bengalensis) is a globally Endangered nocturnal primate with limited health data across its South and Southeast Asian range. Methods: During necropsies of two deceased individuals from northeastern Bangladesh, numerous live adult pinworms were recovered. Results: Morphological examination combined with mitochondrial cox1 gene sequencing identified the parasites as Lemuricola (Protenterobius) nycticebi. Both hosts exhibited severe gastrointestinal and peritoneal lesions consistent with high-intensity helminth infection. This represents the first confirmed record of L. nycticebi in the Bengal slow loris and extends the parasites known geographic range by approximately 3,400 km. Conclusion: Our findings highlight an overlooked parasitic threat to slow lorises. Given that many Bengal slow lorises are rescued or confiscated from the illegal wildlife trade and forest-edge areas in Bangladesh every year and subsequently released into the wild, the results underscore the need for systematic health assessments, including parasitic screening, before repatriation into the wild. Keywords: Parasitic infection, pinworm, gastrointestinal helminths, primates, Nycticebus bengalensis, Strepsirrhines.

Background: Capped langurs ( Trachypithecus pileatus ) are a globally threatened Asian colobine primate and represent the most frequently trafficked primate species in Bangladesh. This species possesses a highly specialized foregut fermentation system adapted for a predominantly folivorous diet. Consequently, inappropriate feeding practices in captivity, particularly among confiscated individuals, often lead to severe and potentially life‐threatening gastrointestinal complications. Methods: We report the clinical presentation, treatment protocol and outcomes of diet‐induced bloat in two juvenile capped langurs (aged 1.5–2 years) confiscated from illegal wildlife trade in Bangladesh. Following 4 months of fruit‐predominant feeding at a temporary housing facility, both animals developed acute bloat upon transfer to a specialized wildlife rehabilitation centre. Results: Clinical signs were severe abdominal distension, lethargy and anorexia. Treatment included oral simethicone (4 mg/kg BID), intramuscular marbofloxacin (2 mg/kg SID for 5 days) and supportive adjunctive treatment in the form of therapeutic abdominal massage. Both langurs had complete clinical recovery within 120 h, with symptomatically discernible improvement within 48 h. Conclusions: This case demonstrates effective multimodal management of bloat in confiscated colobine primates and emphasizes the overriding significance of species‐specific nutrition in wildlife rehabilitation. The described treatment regimen offers evidence‐based guidelines for similar clinical scenarios in captive primate medicine.