Ionizing radiation causes oxidative stress induced tissue damage as well as a decline in reproduction incidence. The purpose of our study was to evaluate the effects of L-carnitine on radiation-induced uterine injury. Thirty Wistar albino rats were classified into five groups. Physiological saline was administered intraperitoneally to the control group. A single dose of 8.3 Gy whole body X-irradiation was applied to the radiation-1 and radiation-2 groups. These groups were sacrificed on the 6^th hour and 4^th day, respectively, after irradiation. Radiation-1 + L-carnitine and radiation-2 + L-carnitine groups received a daily dose of 200 mg/kg L-carnitine in addition to the same dose of irradiation. L-carnitine was also applied one day before and four days after irradiation. L-carnitine therapy partially blocks the depletion of the deep glands and radiation-induced flattening of the glandular epithelium and endometrial surface. Proinflammatory cytokines such as IL-1β, IL-6 and TNF-α were found to be significantly expressed in the uterus tissue of irradiated mice. In the radiation groups, NFκB and PARP-1 expressions in uterine tissue was significantly increased compared to L-carnitine treated and the control groups. It was observed that the oxidative stress index increased in the radiation groups, but decreased in the L-carnitine applied groups. Our findings showed that L-carnitine has a positive effect on radiation-induced uterine damage. L-carnitine may be a potential safe radio protective agent during radiotherapy for pelvic cancer provided the tumor is not protected from radiation damage to the same extent as the normal tissue is. However, prospective clinical trial studies are necessary to understand its efficacy.

Objectives: Oxidative stress is closely associated with atherosclerosis and acute coronary syndromes. The purpose of this study was to evaluate well-known and proportional oxidative stress biomarkers in ST-Elevation Myocardial Infarction (STEMI) patients. Methods: In this single center, prospective and cross-sectional study, 107 individuals (63 patients) were studied. Total oxidative status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), ischemia modified albumin (IMA), myeloperoxidase (MPO), paraoxonase-1 (PON-1) and arylesterase (AREase) enzyme activities as well as MPO/PON-1, MPO/AREase and MPO/HDL-C ratios were studied. As short-term in-hospital prognosis biomarkers; in-hospital mortality, early systolic dysfunction and spontaneous complete revascularization were investigated. Results: Our results indicated that TOS, OSI, IMA, MPO, MPO/PON-1 and MPO/HDL ratios were significantly higher, PON-1 and AREase were significantly lower in STEMI patients compared to the control group. However, in the regression analysis performed by adjusting the differences between the groups, only IMA was found as an independent risk factor (OR=2.711, 95 % CI=1.094–6.719, p=0.031). In terms of in-hospital short-term prognostic biomarkers, a significant relationship was found only between OSI and spontaneous complete revascularization. The OSI value was higher in the group with TIMI grade 3 flow than in the group with TIMI grade 0–2 flow (2.42 [0.81–4.49] vs. 1.63 [0.33–6.07], p=0.016). Conclusions: In STEMI patients, both the well-known (TOS, OSI, and MPO) and proportional (MPO/PON-1 and MPO/HDL cholesterol ratios) oxidative stress markers were elevated and can be considered as having a role in the pathogenesis of STEMI.

Aim: Oxidative stress is one of the causes of contrast-induced nephropathy (CIN). Paraoxonase1 (PON1), is one of the oxidative stress markers. The most sensitive method that has been in use to measure PON1 enzyme activity is the measurement of arylesterase (AREase) activity. To explore relationship between AREase activity and CIN development. Material and Method: A total of 58 STEMI patients were included in our study. The patients were divided into two groups as CIN (+) and CIN (-). The success of AREase activity level in predicting the development of CIN was also examined by using ROC analysis. Results: Out of the study patients, 13 were CIN (+) and 45 were CIN (-). AREase activity was found to be statistically significantly lower in the CIN (+) group (875 U/L vs 819 U/L, p= 0.004). In the regression analysis, diabetes mellitus, contrast volume and AREase activity were determined as independent risk factors in the development of CIN. As a result of the ROC analysis, we concluded that the AREase activity level

B vitaminleri suda çözünebilen vitaminler olup, önemli biyolojik rollere sahiptirler. Her B vitamini, anahtar metabolik süreçler için kofaktördür veya gerekli birer öncüdür. Bilişsel işlevler; hafıza, öğrenme, uzamsal yönelim, akıl yürütme, yargılama ve değerlendirmeyi içeren çeşitli beyin fonksiyonlarıdır. Bu işlevlerin azalması, hafif kognitif bozukluk olarak başlayan ve demansa kadar giden ilerleyici bir durumdur. B vitaminlerinin düşük düzeyde alınması sonucu kognitif bozukluk riskinin artması ve yaşlanmaya bağlı hastalıklara katkıda bulunması tek karbon metabolizması ile ilişkilidir. Bu derlemede B vitaminlerini, tek karbon metabolizmasını ve B vitaminlerinin yaşlanmada beyin sağlığı üzerindeki rolünü inceledik.

C reactive protein is an acute phase protein and is known to be stimulated by liver during inflammatory processes. It has been in use for the diagnosis of infections and for monitoring the course of a disease for a long period of time. The demonstration of a relationship between cardiovascular system and inflammation enhanced the importance of inflammatory markers. Besides bacterial infections, viral infections and rheumatic diseases, CRP levels were also found to be elevated in cardiovascular events such as atherosclerosis. By detecting CRP levels, disease monitoring can be achieved and the risk of cardiovascular diseases for healthy individuals can be determined beforehand. In several studies performed, CRP levels were found significantly high in patients with atherosclerosis, myocardial infarction, arrhythmia, diabetes mellitus and hypertension. More studies are needed to be performed to understand the mechanisms lying between cardiovascular diseases and CRP. understand the mechanisms lying between cardiovascular diseases and CRP. Keywords: Cardiovascular Diseases, C-Reactive protein, Free Radicals.