Dr. Rajamanickam’s research centers on elucidating the molecular and biochemical mechanisms underlying alcohol-associated diseases, with particular focus on alcohol’s deleterious effects on the methionine metabolic pathway, oxidative stress, reproductive toxicity, and metabolic dysfunction. His work also investigates the liver–adipose–gut axis in the progression of alcohol-associated and non-alcoholic liver diseases, with special emphasis on the preventive and therapeutic potential of betaine treatment.