This paper seeks to establish the impact of university experiential learning programs on small- to medium-sized enterprises while emphasizing the benefit to rural workforce development and sustainable manufacturing practices. Data were collected from diverse partners of Louisiana State University’s experiential learning program over the last 7 years to illustrate the types of recommendations and implementation statistics for sustainable manufacturing practices. The study found that rural enterprises favored the adoption of short-term, high-saving solutions to mitigate the impact of utility costs resulting from geographical isolation, while there was low implementation of long-term, large investment projects. This highlighted the practical feasibility of a project over a focus on long-term sustainability plans, which require significant capital investment, management planning, and employee training. This study outlines a university-led experiential learning program’s engagement through academic–industrial partnerships that serve student development and the economic advancement of small- to medium-sized enterprises. The data can direct future incentive opportunities for sustainability projects that have more immediate payback, to increase the adoption rate in rural facilities. The larger implication provides a framework and validation that can support the development of similar programs for extension and enterprise engagement to impact sustainable manufacturing practices.