Simona Stase

Dr. Simona Stase


Research Focus & Metrics

Academic Career Length

2Years (2025-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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4 December 2025 in Medicina
Verified
Journal Article
Open access
PDF file
DBDragos Brezeanu
Dragos Brezeanu
ABAna-Maria Brezeanu
Ana-Maria Brezeanu
SSSimona Stase
Simona Stase
VTVlad Iustin Tica
Vlad Iustin Tica
Background and Objectives: Adolescent pregnancy remains a major global public-health concern, particularly in low- and middle-income countries. Romania consistently reports the highest teenage birth rate in the European Union, with pronounced regional disparities. This study aimed to assess the incidence, sociodemographic predictors, and obstetric outcomes of adolescent pregnancies over a ten-year period in southeastern Romania. Materials and Methods: A retrospective, population-based study was conducted at the Clinical County Hospital “Saint Andrew the Apostle”, Constanța, from 1 January 2014 to 31 December 2023. All deliveries involving mothers aged ≤19 years were identified from institutional databases. Demographic variables (age, residence, education) and obstetric outcomes (mode of delivery, gestational age, neonatal parameters) were analyzed. Statistical tests included Pearson’s χ2, t-tests or Mann–Whitney U tests, and multivariate logistic regression to identify independent predictors of cesarean delivery and preterm birth. Results: Among 13,416 hospital deliveries, 1640 (12.2%) involved adolescent mothers (mean age 16.3 ± 1.4 years). Most originated from rural areas (64.6%) and had only primary education (42.8%). Cesarean section was performed in 58.3% of cases—significantly higher among rural (61.2%) and low-education (62.4%) groups (p < 0.05). The leading indications were cervical dystocia (19.2%) and cephalopelvic disproportion (16.9%). Preterm birth occurred in 30.5% and low birth weight in 27.1% of neonates. Multivariate analysis identified primiparity (OR 2.10; 95% CI 1.45–3.05; p < 0.001) and low education (OR 1.56; 95% CI 1.09–2.21; p = 0.015) as independent predictors of cesarean delivery, while rural residence and low education predicted prematurity (OR 1.84; 95% CI 1.12–3.02; p = 0.016). Conclusions: Adolescent pregnancy in southeastern Romania remains a persistent public-health challenge concentrated among rural and low-education populations. These patterns are consistent with previously described vulnerabilities in adolescent populations, including developmental and healthcare-access challenges, although such factors were not directly measured in this study. Community-based prevention, comprehensive sexual education, and adolescent-friendly obstetric pathways are urgently needed to reduce the burden of teenage pregnancy in Eastern Europe. These associations should be interpreted with caution, as the retrospective design precludes causal inference.

14 November 2025 in Healthcare
Verified
Journal Article
Open access
PDF file
ABAna-Maria Brezeanu
Ana-Maria Brezeanu
DBDragos Brezeanu
Dragos Brezeanu
SSSimona Stase
Simona Stase
Sergiu Ioachim ChirilaSergiu Ioachim Chirila
Sergiu Ioachim Chirila
VTVlad Iustin Tica
Vlad Iustin Tica
Background: Cesarean delivery is a frequent surgical procedure associated with postoperative scarring, which may impact both the aesthetic and functional recovery of patients. Platelet-rich plasma (PRP), a concentration of autologous platelets containing bioactive growth factors, has shown promising effects in promoting wound healing and tissue regeneration. However, its efficacy in enhancing cesarean wound healing remains underexplored. Methods: This single-arm prospective observational study included 50 patients undergoing cesarean section who received intraoperative PRP in two stages: 5 mL applied before hysterorrhaphy and 5 mL injected subcutaneously before skin closure. Scars were assessed at 7 and 40 days using six validated scales (Manchester, Patient and Observer Scar Assessment Scale (POSAS), Vancouver, Visual Analog Scale (VAS), Numeric Rating Scale (NRS), and REEDA (Redness, Edema, Ecchymosis, Discharge, Approximation). Hematological parameters (hemoglobin, hematocrit, leukocyte count, and platelet count) were monitored to correlate systemic inflammatory response and healing progression. Statistical analysis included the Wilcoxon signed-rank test and Pearson correlation. Results: Mean scar scores improved significantly from 8.88 ± 2.13 at day 7 to 6.46 ± 1.23 at day 40 (p < 0.001). Hematological parameters improved between day 7 and day 40, reflecting the expected course of postoperative recovery; these were considered secondary outcomes. Exploratory analyses revealed correlations between hemoglobin and POSAS (r = 0.42, p < 0.05), leukocyte count and REEDA (r = 0.68, p < 0.01), and platelet count and POSAS (r = −0.48, p < 0.05). Conclusions: Intraoperative PRP administration significantly enhanced postoperative scar healing after cesarean delivery and was associated with reduced inflammation and improved hematological recovery. These findings support the use of PRP as an adjunctive regenerative therapy in obstetric surgery. Randomized controlled trials are warranted to validate efficacy of the intervention, and moreover long-term outcomes.

13 April 2026 in Life
Verified
Journal Article
Open access
PDF file
DBDragos Brezeanu
Dragos Brezeanu
ABAna-Maria Brezeanu
Ana-Maria Brezeanu
SSSimona Stase
Simona Stase
VTVlad Iustin Tica
Vlad Iustin Tica
Background: Water birth has gained increasing attention as an alternative childbirth method intended to promote maternal comfort and physiological labor while potentially reducing obstetric interventions. However, evidence regarding its maternal and neonatal safety compared with conventional delivery approaches remains heterogeneous. This study aimed to evaluate maternal and neonatal outcomes associated with water birth compared with conventional spontaneous vaginal delivery in a secondary obstetric center. By focusing on vaginal births, the study evaluates the specific impact of water immersion on perineal integrity and neonatal transition. Methods: We conducted a retrospective cohort study including 3747 deliveries recorded at a tertiary maternity unit over a five-year period. Among these, 692 births occurred in water (water birth group) and 561 were conventional vaginal deliveries (land birth group), both managed under a standardized institutional protocol. Maternal characteristics, obstetric outcomes, and neonatal parameters were extracted from medical records and compared between the two cohorts. Primary outcomes included rates of episiotomy, perineal trauma and neonatal indicators such as Apgar score. Statistical analyses were performed to assess differences between groups using appropriate comparative tests. Results: Water birth was associated with a significantly lower rate of episiotomy compared with land birth (5.06% vs. 13.72%, OR 0.33, 95% CI 0.22–0.50, p < 0.001). Neonatal outcomes, including Apgar scores and NICU admissions, did not differ significantly between the two cohorts. Conclusions: In this retrospective cohort, water birth among selected low-risk pregnancies was associated with reduced obstetric intervention, particularly episiotomy, without evidence of adverse neonatal outcomes. These findings suggest that water birth may represent a safe and feasible option in carefully selected low-risk pregnancies when strict clinical protocols are applied.