Background: Severe obesity is a growing global health challenge, and metabolic bariatric surgery (MBS) is an effective treatment. However, the clinical relevance of routine preoperative thyroid assessments remains unclear. This cross-sectional study investigated the relationship between baseline thyroid-stimulating hormone (TSH) levels and other biochemical parameters during preoperative MBS. Patients and Methods: Over 12 months (June 2024 to June 2025), 208 patients aged > 15 years undergoing preoperative evaluation for MBS at our referral center were considered for the study. Patients with prior bariatric/major abdominal surgery, active thyroid disease or thyroid-active medications (with a 3-month washout), or acute severe illness were excluded from the study. Fasting blood serum TSH was measured within one week before hospital admission, categorized using standard cutoffs, and statistical analysis was performed. Results: The mean age and preoperative body mass index (BMI) were 36.6 ± 11.2 years and 43.7 ± 6.4 kg/m2 (range 33.05-84.0), respectively. The serum TSH levels ranged from 0.02 to 14.13 (mean: 1.70 ± 1.46 mIU/L). The serum creatinine and albumin levels demonstrated a mean value of 61.3 ± 14.3 µmol/L (range: 37.8-155 µmol/L) and 43.2 ± 2.6 g/L (range: 36-50 g/L), respectively. Correlation analyses showed no statistically significant associations between TSH and age, BMI, HbA1c, hemoglobin, creatinine, or albumin levels (Pearson and Spearman coefficients). The prevalence of TSH abnormalities was not significantly different according to age group (χ2 = 6.106, p = 0.978) or gender (χ2 = 1.445, p = 0.695). Multivariable linear regression for log-transformed TSH showed that age, BMI, HbA1c, and creatinine were not significant predictors. Most patients were euthyroid (92.8%), with 3.8% low TSH. Further, TSH levels showed no significant correlations with BMI (r = 0.032), hemoglobin, HbA1c, creatinine, or albumin, and did not differ by age group or gender. Conclusions: These findings suggest that, in patients with severe obesity undergoing preoperative evaluation for MBS, TSH levels are generally within the reference range and are not statistically influenced by the measured biochemical or demographic factors. This supports a more clinically driven approach to thyroid testing while emphasizing the need for larger, multicenter, and longitudinal studies to clarify thyroid-obesity relationship and postoperative outcomes.