Periodontitis is a group of inflammatory diseases affecting the supporting tissues of the tooth (periodontium). The periodontium consists of four tissues : gingiva, alveolar bone and periodontal ligaments. Tobbaco use is one of the modifiable risk factors and has enormous influance on the development, progres and tretmen results of periodontal disease. The relationship between smoking and periodontal health was investigated as early as the miiddle of last century. Smoking is an independent risk factor for the initiation, extent and severity of periodontal disease. Additionally, smoking can lower the chances for successful tretment. Tretmans in patients with periodontal disease must be focused on understanding the relationship between genetic and environmental factors. Only with individual approach we can identify our pacients risks and achieve better results.

Regenerative endodontic approaches for immature necrotic permanent teeth must balance biological efficacy, clinical practicality and long-term aesthetic outcomes. This study evaluates a novel regenerative protocol using autologous advanced platelet-rich fibrin plus (A-PRF+) scaffold sealed exclusively with glass ionomer cement (GIC) and compares it to conventional calcium hydroxide apexification used as the control. Twenty-eight patients were prospectively enrolled and followed for 12 months alongside a retrospectively selected historical control group. Outcomes were evaluated through standardised blinded clinical, radiographic and vitality assessments. The A-PRF+ protocol demonstrated significantly faster periapical healing, superior root lengthening, increased dentinal wall thickness and apical closure (p < 0.0001), with excellent aesthetic outcomes and no reported tooth discolouration. Pulpal blood flow measured by laser Doppler flowmetry indicated vitality restoration in 93% of cases. Preliminary linear regression identified treatment duration as a significant predictor of apical closure (p < 0.0001), with possible enhancement by additional patient-specific variables. These findings validate the A-PRF+ protocol as a highly effective, aesthetically favourable and predictable regenerative strategy, establishing a new benchmark for the management of immature necrotic teeth and laying the foundation for personalised predictive endodontic care. Future studies should include multicentre randomised controlled trials to confirm long-term clinical sustainability and generalisability.

Background and Objective: Immature maxillary incisors (IMIs) are especially susceptible to failure due to their thin dentinal walls and compromised structural integrity following endodontic treatment. This study aims to evaluate the stress distribution within the root dentin after various post-endodontic treatments. Materials and methods: A personalized finite element analysis model of IMI was created using cone beam computed tomography (CBCT) data. Based on data from the literature, five stages of root development were reconstructed: half root development (S1), three-quarter development (S2), more than three-quarter development (S3), fully developed root with open apex (S4), and fully developed root with closed apex (S5). Six experimental groups were analyzed: GC Fiber Post (PS1); RelyX Post (PS2); metal post Unimetric 1.0 (PS3); everStick Post (PS4); positive control group with only the gutta-percha filling (PC), and intact maxillary incisor as negative control group (NC). The resulting equivalent stresses were evaluated using the Hencky–von Mises (HMH) strength theory. Results: The mean HMH stress within the root dentin was statistically significantly higher at the cervical level in all stages, except in stage S1 and models PS2 and PS3 in stage S2, where it was significantly higher at the apical level (p < 0.001 for all models, except stage S3 [PC model p < 0.005; NC model p < 0.008]). The PS4 model showed the lowest stress values at the cervical level in stages S1, S2, and S3 (55.19 MPa, 58.78 MPa, 58.84 MPa) and the PS1 model in stages S4 and S5 (57.48 MPa, 58.81 MPa). At the apical level, model PS3 showed the lowest stress values in stage S1 (69.60 MPa), model PS1 in stages S2, S3, and S5 (35.99 MPa, 44.30 MPa, 12.51 MPa) and model PC in stage S4 (17.85 MPa). Conclusions: The results showed that the greatest stress in an immature maxillary central incisor occurred at the cervical level, except during the early stage of root development. Post placement did not reduce root dentin stress.