Introduction: In renal transplant recipients (RTRs), kidney graft failure and cardiovascular (CV) disease are prevalent and associated with mortality. Objectives: The objective of the study was to evaluate biomarkers, (cardiac troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP)), to identify RTRs who are at greater risk of death, CV event, and graft renal survival. Patients and methods: A total of 342 stable RTRs were enrolled in this study, with a median follow-up time of 54 months. The probability of death, CV event, and renal graft survival were calculated using Kaplan–Meier analysis for the group defined by cTnT and NT-proBNP levels above the cutoff values. Results: The probability of death for troponin T level above the cut-off was 23% and for NT-proBNP 29%. For CV events the probability for troponin T was 20% and for NT-proBNP it was 21%. Troponin T concentrations above the cutoff point suggested a 25% probability of death-censored graft survival. For NT-proBNP, it was 26%. The probability of overall graft survival was 38% for patients with higher troponin T levels, and 40% for NT proBNP. Conclusions: These data suggest that cTnT and NT-proBNP could potentially identify patients at high risk for death, CV event, and graft survival.

In renal transplant recipients (RTRs), kidney graft failure and cardiovascular disease are prevalent and associated with morbidity and mortality. Objectives:The objective of the study was to evaluate biomarkers, such as cardiac troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), to identify RTRs who are at greater risk of experiencing unfavorable outcomes, including all-cause mortality, renal, and cardiovascular (CV) events, as well as to assess the influence of these biomarkers on overall and death-censored graft survival. Patients and methods: A total of 342 stable RTRs were enrolled in this study, with a mean follow-up time of 48.4 months and a median follow-up time of 54 months. The probability of death, CV, and renal events at 4.9 years was calculated using Kaplan-Meier analysis for the group defined by cTnT and NT-proBNP levels above the cutoff values. Results: The probability of death and CV events was 23%, 20%, and 29%, 19%, for cTnT and NT-proBNP levels above the cutoff values, respectively. The probability of renal events, overall graft survival, and death-censored graft survival was 68%, 38%, 25%, and 63%, 41%, 27%, respectively. Conclusion: These data suggest that cTnT and NT-proBNP could potentially identify patients at high risk for death, CV, and renal events, as well as for overall graft survival and death-censored graft survival.