Centrifugal irrigation pumps in Southern Xinjiang face severe performance degradation due to high fine-sediment loads in canal water. This study combines Eulerian multiphase simulations with experimental validation to investigate the coupled effects of sediment size (0.05~0.8 mm) and concentration (5~20%) on hydraulic performance. Numerical models incorporating Realizable k–ε turbulence closure and discrete phase tracking reveal two critical thresholds: (1) particle sizes ≥ 0.4 mm trigger a phase transition from localized disturbance to global flow disorder, expanding low-pressure zones by 37% at equivalent concentrations; (2) concentrations exceeding 13% accelerate nonlinear pressure decay through collective particle interactions. Velocity field analysis demonstrates size-dependent attenuation mechanisms: fine sediments (≤0.2 mm) cause gradual dissipation via micro-scale drag, while coarse sediments (≥0.6 mm) induce “cliff-like” velocity drops through inertial impact-blockade chains. Experimental wear tests confirm simulation accuracy in predicting erosion hotspots at impeller inlets/outlets. The identified synergistic thresholds provide critical guidelines for anti-wear design in sediment-laden irrigation systems.