Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease. Immune system cells have an important role in RA. Our aim was to investigate the relationship between disease activity, systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV) levels in RA patients. We planned to investigate whether these 2 measurements have an advantage over each other. About 67 patients diagnosed with RA and 49 healthy controls included in this study. RA was diagnosed based on 2010 ACR classification criteria. In this cross-sectional study, peripheral blood tests, C-reactive protein (CRP), hemogram, and erythrocyte sedimentation rate levels were noted after the physical examination of all participants. PIV was calculated with the formula: (neutrophil count × platelet count × monocyte count) / lymphocyte count. SII was calculated as follows: (neutrophil count × monocytes count) / lymphocyte count. The disease activity score 28 (DAS28) were noted in patients with RA. CRP values of active RA group were significantly higher than remission RA and control groups (P < .001), control and remission RA groups were similar (P = .86). PIV and SII are significantly higher in active RA than remission RA and control (P < .001, P < .001) higher in remission RA than control (P < .001, P < .001). Receiver operating characteristic curve analysis in predicting remission compared to the control group, CRP was not significant, PIV and SII was significant and PIV has higher sensitivity and sensitivity, a PIV value of > 217.31 have sensitivity 75.0% and specificity 85.7%. CRP, PIV, and SII are statistically significant in predicting active RA compared to the remission RA and control group. Our findings show that PIV, and SII are easy, inexpensive and reliable markers predicting remission in RA patients. CRP was not significant compared to remission RA and control group, PIV and SII was significant and PIV has higher sensitivity and specificity than SII in the remission group in RA. Patients with high disease activity, PIV, SII, and CRP levels were effective in showing disease activity compared to RA remission group and healthy controls.

Vitamin D adipoz dokuda eriyen sekosteroid yapıda bir hormon olup en önemli etkisi kemik metabolizması ve serum kalsiyum dengesi üzerindedir. Vitamin D eksikliği ve yetersizliği kanser, enfeksiyöz hastalık, metabolik sendrom, hipertansiyon, miyokard enfarktüsü ve kardiyovasküler hastalık sonucu ölüm riskinin artması, multipl skleroz, romatoid artrit, tip I diyabet dahil olmak üzere bir çok otoimmün hastalıkların insidansı ve şiddeti ile ilişkilendirilmiştir. Vitamin D’nin optimal düzeyi hakkında bir fikir birliğine varılmamış olsa da çoğu araştırmacı tarafından 25(OH)D düzeyinin; 30 ng/mL’nin üzerindeki değer yeterli, 20 ile 30 ng/mL arasındaki değer yetersizlik, 20 ng/mL’nin altındaki değer eksiklik olarak kabul edilir. Ülkemizde vitamin D eksikliğinin sık görülmesi ve vitamin D eksikliğinin kanser, sistemik hastalıklar ve kemik sağlığı üzerine olumsuz etkilerinden dolayı bu derlemede, erişkinlerde D vitamini fizyolojisinin anlaşılması, vitamin D eksikliğinin tanımlanması ve tedavi sürecinde güncel yaklaşım sunmayı amaçladık.