This article presents a clinical case of melanoma associated with pregnancy, which had an extremely aggressive course leading to the death of the patient. The case illustrates the negative impact of pregnancy on the clinical course of melanoma, with less than a month passing from the appearance of the first clinical signs to the patient's death. An analysis of the modern literature indicates on the frequency of occurrence and features of the clinical course of melanoma during pregnancy showed that pregnant women diagnosed with melanoma have a less favorable prognosis for the development of the disease compared to non-pregnant women. В статье представлен клинический случай меланомы, ассоциированной с беременностью, показано крайне агрессивное течение заболевания, приведшее к летальному исходу беременной пациентки. Представленный клинический случай наглядно продемонстрировал негативное влияние беременности на клиническое течение меланомы: от момента появления первых клинических признаков до смерти пациентки прошло меньше месяца. Современный анализ литературы по частоте встречаемости и особенностях клинического течения меланомы на фоне беременности показал, что беременные женщины на момент диагностики злокачественного заболевания имеют менее благоприятный прогноз развития меланомы, чем не беременные.

Objectives: The aim of this study is to demonstrate the efficacy of the modified technique of radical organ-preserving surgery of invasive cervical cancer (CC) in patients of reproductive age. Methods: This study included 118 patients of reproductive age (34.9 ± 4.8 years) with a morphologically verified diagnosis of invasive CC (T1a-1bNxM0). All patients underwent organ-preserving surgery in the scope of radical trachelectomy. A shape memory mesh implant woven in the form of a stocking from superelastic nickelide titanium thread with subsequent fixation with separate sutures around the perimeter was used to form the uterine closure apparatus and to strengthen the utero-vaginal anastomosis. The mesh implant was made of superelastic thin nickelide titanium threads with a diameter of 60–40 microns on a metal knitting machine. All patients were prospectively followed up for a mean of 120 months. Results: No intraoperative or postoperative complications were revealed when using a shape memory implant made of titanium nickelide during radical trachelectomy to form a locking apparatus and strengthen the anastomosis zone. No cervical stenoses or mesh failures were noted in any case. The 5-year overall and recurrence-free survival rates were 100% and 98%, respectively. Two patients indicated recurrence; it occurred in 3 and 36 months. There were 42 spontaneous pregnancies, and 29 resulted in full-term delivery, whereas 2 and 11 ended in miscarriage and early abortion, respectively. Currently, 18 patients are at different stages of the use of assisted reproductive technologies. Conclusions: The shape memory implant made of titanium nickelide integrates well into the surrounding tissues and successfully imitates the effect of the cervix. The use of this sparing-surgery technique has shown reasonably good results in carrying the pregnancy to term and good reproductive outcomes.