Vibration control remains a critical factor in the design and operation of high-speed vessels, particularly for coastal patrol craft where structural safety, crew comfort, and operational reliability are paramount. This study presents the experimental validation of a 28-meter coastal patrol craft through full-scale vibration measurements conducted during sea trials. A dedicated measurement system was engineered, calibrated, and installed to capture vibration responses across various operating conditions, including speed ramp-up tests and hard-over turns to both port and starboard. Measurements were taken at multiple locations in three axes longitudinal, transverse, and vertical and evaluated against classification society criteria and ISO 20283-5:2016 standards. The highest vibration levels were observed in the aft deck, steering gear area, and radar mast, yet all readings remained within acceptable thresholds. The results confirm the adequacy of the vessel’s structural design and propulsion arrangement, supporting its readiness for active deployment without the need for vibration mitigation devices. The methodology and findings offer a practical framework for assessing and verifying vibration performance in similar high-speed marine craft.