With substantial temperature differentials between summer and winter in polar regions, there exists a pressing necessity for flexible sensors capable of functioning across a broad temperature spectrum to facilitate the construction of a more intelligent human–machine interface. Nevertheless, developing flexible sensors resilient to extremely low temperatures remains a significant challenge. In this study, we present an organohydrogel capable of functioning ranging from ambient to −78 °C, enabling real-time monitoring of multi-source signals, including motion, physiology, speech, and pressure. We synthesize organohydrogel employing a singular methodology: interpenetrating network structures as matrix frameworks, dynamic hydrophobic linkages as the physical cross-linking points, and incorporating a bionic binder. H-Bonding and chain entanglement synergistic supramolecular interactions build the organohydrogel matrix with microphase-separated domains, which, together with the combination of binary solvents and inorganic salts, allows it to exhibit excellent properties, including large stretchability (≈1700%), high ionic conductivity (1.57 S m⁻¹), admirable sensing sensitivity performance (gauge factor: GF = 6.47, S = 0.32 kPa⁻¹), an exceptionally low-pressure detection threshold (≈1 Pa), enables wireless transmission of distress signals through human–machine interaction even at −78 °C, which makes it possible to use it in polar exploration and to give robots a “sense of touch” for a variety of deep-diving tasks.