Xiran Chen

Dr. Xiran Chen

orcid

Research Focus & Metrics

Academic Career Length

2Years (2025-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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26 March 2026 in BMC Bioinformatics
Verified
Journal Article
Open access
PDF file
XTXingyue Tan
Xingyue Tan
XCXiran Chen
Xiran Chen
RTRenjie Tian
Renjie Tian
QCQinyu Cai
Qinyu Cai
MJMiaoyuan Jiang
Miaoyuan Jiang
LZLei Zhang
Lei Zhang
Cancer heterogeneity poses a major challenge for accurate molecular subtype classification. Conventional methods often fail to exploit complementary inform

19 May 2025 in bioRxiv
Verified
Preprint
Open access
PDF file
XTXingyue Tan
Xingyue Tan
XCXiran Chen
Xiran Chen
RTRenjie Tian
Renjie Tian
QCQinyu Cai
Qinyu Cai
MJMiaoyuan Jiang
Miaoyuan Jiang
XGXianghui Guo
Xianghui Guo
Cancer heterogeneity poses a major challenge for accurate molecular subtype classification. Conventional methods often fail to exploit complementary information across multiple omics modalities, leading to overfitting on high-dimensional data and limited representation of subtype heterogeneity. To address this, we propose Triad-LMF, a multiomics integration framework based on low-rank multimodal fusion to improve classification accuracy. Triad-LMF harmonizes heterogeneous omics data and integrates information through a two-stage hierarchical fusion strategy. Local Pairwise Fusion and Global Triadic Fusion are combined via the Two-Feature and Three-Way LMF modules, enabling a gradual transition from local modality interactions to global feature integration. Experimental results show that Triad-LMF consistently outperforms existing methods. UMAP visualization confirms enhanced subtype separability, and SHAP-based analysis highlights biologically meaningful features. Across independent datasets, Triad-LMF demonstrates strong generalization, offering a robust and interpretable framework for multiomics-driven cancer subtype classification.