Background and Objectives: Diabetic foot disease is a major cause of lower-limb amputation and is associated with substantial morbidity and mortality. While amputation is often considered definitive treatment, postoperative outcomes and their predictors remain incompletely characterized. Materials and Methods: This retrospective cohort study included all patients who underwent diabetic foot amputation at a tertiary care center between January 2015 and August 2025. Demographic data, comorbidities, laboratory parameters, and amputation-related variables were collected. The primary outcome was postoperative complications. Secondary outcomes included readmission, re-amputation, ICU admission, length of stay, and mortality. Logistic regression was used to identify predictors of postoperative complications. Results: A total of 437 patients were included (mean age 62.0 ± 11.8 years; 65.7% male). Postoperative complications occurred in 52.1% of patients, most commonly infections (31.6%) and acute kidney injury (18.1%). Readmission occurred in 50.6%, re-amputation in 23.4%, ICU admission in 28.7%, and mortality in 17.8%. On multivariable analysis, preoperative serum albumin was the only independent predictor of postoperative complications (aOR 0.944, 95% CI: 0.913–0.976; p < 0.001). Conclusions: Postoperative complications following diabetic foot amputation are common and associated with significant healthcare utilization and mortality. Preoperative hypoalbuminemia was the only independent predictor of postoperative complications, supporting its utility as an integrated biomarker of systemic illness (including inflammatory burden/infection and hepatic synthetic function) for perioperative risk stratification.

Background: Signal transducer and activator of transcription 3 (STAT3) gain-of-function (GOF) disease is a rare autosomal dominant primary immunoregulatory disorder characterized by early-onset autoimmunity, lymphoproliferation, recurrent infections, and multisystem involvement. Marked phenotypic heterogeneity and overlap with other immune dysregulation occasionally result in delayed diagnosis with detrimental prognostic implications. Case Presentation: We report a 27-year longitudinal follow-up of a male patient who first presented at 18 months of age with recurrent pyrexia, failure to thrive, pallor, hepatosplenomegaly, and generalized lymphadenopathy. Initial investigations revealed persistent pancytopenia, impaired vaccine responsiveness, and hypergammaglobulinemia with a monoclonal spike. In the absence of a definitive diagnosis, the patient was treated with monthly intravenous immunoglobulin (IVIG) for 26 years and remained largely infection-free for 26 years. Over time, the patient developed progressive multisystem disease including short stature refractory to growth hormone therapy, end-stage renal disease, portal hypertension, and neuropsychiatric deterioration. Genetic testing performed in adulthood identified a heterozygous likely pathogenic STAT3 variant (c.1974G > T; p.Lys658Asn), consistent with STAT3 GOF disease. The patient died shortly after elective splenectomy performed for portal hypertension and refractory cytopenias. Discussion: This case illustrates the protean manifestations and diagnostic complexity of STAT3 GOF disease. The clinical course was consistent with known features—autoimmune cytopenias, lymphoproliferation, growth failure, and impaired vaccine responses—while also expanding the phenotypic spectrum to include pronounced dysmorphic features and severe growth impairment. Notably, therapy with prophylactic IVIG was particularly effective in preventing severe infection. STAT3 GOF is a relevant diagnostic consideration in patients with early-onset multisystem autoimmune disease, persistent lymphoproliferation, recurrent infections, and abnormal vaccine responses.

Background/Objectives: Traumatic spinal injury (TSI) is associated with substantial morbidity, but factors contributing to in-hospital complications remain insufficiently defined. This study evaluated factors associated with in-hospital complications after TSI. Methods: We conducted a retrospective cohort study at a tertiary center (January 2018–May 2025). Among 5380 trauma patients screened by computed tomography, 413 admitted patients with TSI were included. The primary outcome was any documented in-hospital complication. Factors were assessed using multivariable logistic regression and reported as adjusted odds ratios (ORs) with 95% confidence intervals (CIs). Results: The median age was 28.0 years, 337 were male (81.6%), and four-wheel motorized vehicle accidents were the most common injury mechanism (57.1%). In-hospital complications occurred in 99 patients (24.0%). Pulmonary infection was most common (9.9%), followed by bloodstream infection (4.4%), urinary tract infection (3.9%), and surgical site infection (3.9%). Compared with patients without complications, those with complications had longer hospital stays, higher ICU admissions, longer ICU stays, and lower discharge home. In multivariate logistic regression, complications were associated with worse AIS grade (OR 1.690, 95% CI 1.241–2.302), inpatient physical therapy requirement (OR 4.385, 95% CI 2.494–7.711), greater number of associated non-spinal injuries (OR 1.729, 95% CI 1.463–2.042), and greater cervical vertebral injury burden (OR 1.479, 95% CI 1.061–2.062). Conclusions: Neurological severity, polytrauma burden, and cervical injury were independently associated with complications, supporting early risk stratification and multidisciplinary prevention in high-risk patients. Findings should be interpreted considering the retrospective single-center design, predominantly young male cohort, low spinal cord injury proportion, and limited post-discharge data.