During the transition from urban expansion to renewal, optimizing environmental comfort under resource constraints presents critical challenges. While existing research confirms that multisensory interactions critically shape environmental comfort, these insights are rarely operationalized into protocols for resource-constrained contexts. Focusing on historic urban quarters that need to balance modification and preservation, this study quantifies multisensory (acoustic, visual, thermal) interactions and integrations to establish operational resource-optimization strategies. Through laboratory reproduction of 144 field-based experimental conditions (4 sound sources × 3 sound pressure levels × 4 green view indexes × 3 air temperatures), systematic subjective evaluations of acoustic, visual, thermal, and overall comfort were obtained. Key findings demonstrate: (1) Eliminating extreme comfort evaluations (e.g., “very uncomfortable”) within any single sensory domain stabilizes cross-sensory contributions to overall comfort, ensuring predictable cross-domain compensations and safeguarding resource efficacy; (2) Accumulating modest improvements across ≥2 sensory domains reduces per-domain performance threshold for satisfactory overall comfort, enabling constraint resolution (e.g., visual modification limits in historic districts); (3) Cross-domain optimization of environmental factors (e.g., sound source and air temperature) generates mutual enhancement effects, maximizing resource economy, whereas intra-domain optimization (e.g., sound source and sound pressure level) induces competitive inefficiencies. Collectively, these principles establish operational strategies for resource-constrained environmental improvements, advancing sustainable design and governance through evidence-based multisensory approaches.