Objectives: Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterized by recurrent, self limited attacks of fever with serositis. The aim of this study was to describe the frequency of musculoskeletal complaints in children with FMF and to investigate the effect of genotype on these findings. Methods: Files of patients who had been seen in our department (during routine follow-up visits) were retrospectively evaluated. Comparisons regarding musculoskeletal findings were performed between patients with homozygous/compound heterozygous and heterozygous mutations. Thereafter, patients with two mutations were divided into three groups; M694V/M694V, M694V/other mutation and patients carrying two mutations other than M694V. Patients with single mutation were divided into two groups; M694V and non M694V carriers. Results: The study group comprised 317 FMF patients (170 females) with a mean age of 12.2 ± 5.7 years. Arthralgia (42.6%), leg pain (42.9%) and heel pain (35.6%) were the most common musculoskeletal complaints in children with FMF. Frequency of musculoskeletal findings of the patients who had two mutations did not differ from the patients with single mutations (p>0.05). Leg and heel pain were more frequently detected in patients with homozygous M694V mutation (p=0.001). Among patients with heterozygous mutations; children with M694V mutation had more frequently arthralgia, leg and heel pain (p<0.05). Conclusions: Musculoskeletal problems were commonly encountered in patients with FMF. Genotype seems to affect the frequency of these problems and M694V mutation is a predisposing factor for musculoskeletal complaints.

What is already known on this topic? The European-Thyroid Imaging Reporting and Data System (EU-TIRADS) is a risk stratification system used to evaluate the probability of malignancy in thyroid nodules, based on ultrasound characteristics. This scoring system assists clinicians in determining whether to suggest biopsy or further monitoring of thyroid nodules. The EU-TIRADS scoring system has undergone comprehensive investigation in adult populations, demonstrating acceptable accuracy in the prediction of malignancy. The EU-TIRADS scoring system has the potential to be a useful tool for evaluating thyroid nodules in children, but its accuracy and effectiveness still require confirmation.

Bu çalışmada, hem bireysel hem de örgütsel anlamda sorun teşkil eden ve işletmelerde maliyeti artıran tükenmişliğin otellerde incelenmesi ile bu durumun çalışanların yaşam doyumuna etkisinin belirlenmesi amaçlanmıştır. Bu amaçla Antalya ve İstanbul otellerinde çalışan 418 bireye anket uygulanmıştır. Araştırma sonucunda; kadınların erkeklere göre daha fazla tükenmişlik yaşadığı tespit edilmiştir. Ayrıca otelin konumuna göre tükenmişlik ve yaşam doyum düzeylerinin farklılaştığı ve sayfiye bölgesindeki otellerin daha fazla tükenmişlik ile daha az yaşam doyumuna sahip olduğu belirlenmiştir. Araştırma sonunda otel çalışanlarının duygusal tükenme, duyarsızlaşma, düşük kişisel başarı hissi ve genel tükenmişlik düzeyleri arttıkça yaşam doyumunun azaldığı ortaya çıkmıştır.

Krukenberg tumor (KT) is a rare ovarian carcinoma containing mucin-filled signet ring cells. It accounts for 1%–2% of all ovarian tumors. It is seen at an average age of 40 years. Reported pediatric cases of KT in the literature are very limited. Herein, we present an adolescent with a KT that was compatible with metastatic ring cell colon carcinoma.

\received DD MMMM YYYY \acceptedDD MMMM YYYY Background: Febrile neutropenia (FN) is a common and potentially life-threatening complication in pediatric oncology. Early identification of sepsis is critical for timely intervention. Presepsin (PSP), a soluble CD14 subtype, has been proposed as a potential biomarker for infection. This study aimed to evaluate the diagnostic and prognostic value of PSP compared with CRP and procalcitonin (PCT) in pediatric cancer patients with FN. Methods: This prospective observational study included 60 pediatric oncology patients with FN and 20 age-matched febrile controls. PSP, CRP, and PCT levels were measured at baseline, onset of fever, and 48 hours post-onset. ROC curve analysis determined optimal PSP cut-off values. Statistical analyses included Mann–Whitney U, Spearman correlation, and generalized linear models. Results: CRP and PCT levels increased significantly in both groups during febrile episodes (p<0.001). PSP levels increased significantly only in febrile controls (p<0.001) but not in oncology patients (p=0.247). In FN patients, a PSP cut-off of 2768 pg/mL yielded 34.4% sensitivity, 84.4% specificity, and 85% negative predictive value (NPV). PSP did not significantly correlate with CRP or PCT. Conclusions: While PSP demonstrated high NPV, its low sensitivity limits its utility as a standalone biomarker in pediatric oncology patients with FN. CRP and PCT remain more reliable for clinical decision-making. Larger multicenter studies are warranted to validate PSP’s role in multimodal risk assessment.