Background/Objectives: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for postpartum pain management. However, previous studies have indicated that NSAIDs may increase systolic blood pressure, particularly in patients receiving antihypertensive therapy. The aim of the present study was to assess whether postpartum ibuprofen administration is associated with a higher risk of severe postpartum hypertension and increased mean arterial pressure (MAP) compared with acetaminophen. Methods: A systematic literature search was conducted in PubMed, Scopus, and Web of Science to identify relevant studies. Only randomized controlled trials were considered eligible for inclusion. For dichotomous outcomes, effect sizes were expressed as risk ratios (RRs) with corresponding 95% confidence intervals (CIs). For continuous outcomes, mean differences (MDs) with 95% CIs were calculated. Statistical heterogeneity among studies was assessed using the I² statistic. A fixed-effects model was applied in cases of low heterogeneity (I² < 20%). Results: No significant difference was observed in the prevalence of severe postpartum hypertension between the ibuprofen and acetaminophen groups (RR 1.07, 95% CI 0.84 to 1.35; p = 0.59; I² = 0%). Similarly, MAP did not differ significantly between groups (MD −0.05 mmHg, 95% CI −1.53 to 1.42; p = 0.94; I² = 0%). Conclusions: No increased risk of postpartum hypertension or difference in mean arterial pressure was observed between the ibuprofen and acetaminophen groups, supporting the safety of ibuprofen for postpartum analgesia in women with hypertensive disorders of pregnancy.

Background: This study aimed to systematically review and analyze the available evidence on the safety and efficacy of physical activity (PA) in patients with HCM. Methods: We conducted a systematic search of PubMed, Cochrane, and Web of Science databases up to March 30, 2025. Fourteen studies (4 RCTs) were included in the qualitative synthesis and ten in the quantitative synthesis, totaling 10478 patients. Results: The meta-analysis demonstrated a significant improvement in peak VO₂ in the moderate intensity PA (MIPA) group, with a mean difference of 1.77 mL/kg/min (95% CI: 0.93 to 2.60, I² = 38.2%, p = 0.19), while changes in body mass index were not significant (MD: −0.66 kg/m²; 95% CI: −1.77 to 0.44; I² = 62%; p = 0.07). No significant differences were observed in the occurrence of non-sustained ventricular tachycardia (NSVT) (OR = 1.54, 95% CI: 0.93 to 2.52, I² = 28.3%, p = 0.24), atrial fibrillation (OR = 0.89, 95% CI: 0.77 to 1.03, I² = 28.6%, p = 0.23), or syncope (OR = 1.23, 95% CI: 0.72 to 2.10, I² = 25.6%, p = 0.24) between the MIPA and sedentary group. Additionally, the occurrence of NSVT between the high-intensity PA and MIPA group showed no significant difference (OR = 1.19, 95% CI: 0.60 to 2.36, I² = 0%, p = 0.99). Conclusion: The results suggest that regular exercise does not increase the risk of NSVT, AF, or syncope while enhancing peak VO₂, indicating that regular exercise is safe and beneficial in HCM patients.