We developed a Pd-catalyzed intermolecular reductive Heck reaction to construct Csp²–Csp³ bonds between aryl bromides and olefins.

(NHC)-Cu-catalyzed C(sp)–C(sp³) bond formation has been successfully achieved under mild conditions.

An efficient Ni-catalyzed C3-alkylation of indoles with alcohols via a borrowing hydrogen pathway was achieved utilizing an N,O-donor coordinated nickel complex as the precatalyst.

The Negishi coupling has been widely applied in organic synthesis, while relevant mechanistic studies are relatively rare. To obtain an understanding of the fundamental steps in the Negishi coupling, oxidative addition, transmetalation and reductive elimination, the kinetic investigation has served as one of the most important strategies. In this review, insights into the elementary steps in the Negishi coupling through kinetic investigations are summarized.