Background: Preeclampsia is a complex hypertensive disorder of pregnancy associated with significant maternal and foetal morbidity and mortality. Its pathogenesis involves placental hypoxia, oxidative stress, and impaired trophoblast invasion. Recent evidence highlights the role of microRNAs, particularly microRNA-210 (miR-210), in the molecular disruptions underlying preeclampsia. Aim: This study aims to explore the pathogenic, diagnostic, and therapeutic significance of miR-210 in preeclampsia, with emphasis on its molecular mechanisms, biomarker potential, and prospects as a therapeutic target. Methods: A systematic narrative review was conducted following PRISMA guidelines. A total of 498,184 articles were identified through eight scientific databases, and, after duplicate removal and eligibility screening, 111 peer-reviewed studies published between 2015 and 2025 were included in the final analysis. The selected literature focused on miR-210’s expression in placental tissue and maternal circulation, its molecular targets, and its clinical relevance. Results: miR-210 is consistently upregulated in preeclamptic placentas and maternal plasma. It contributes to shallow trophoblast invasion, impaired angiogenesis, mitochondrial dysfunction, and the activation of a hypoxia-induced HIF-1α feedback loop. These mechanisms are central to the disease’s pathophysiology. Clinically, miR-210 demonstrates high stability in circulation and early detectability, making it a promising diagnostic and prognostic biomarker. Experimental models have also demonstrated the therapeutic potential of miR-210 inhibition using antisense oligonucleotides or HIF-1α modulators. Conclusions: miR-210 is both a marker and mediator of preeclampsia. Its integration into diagnostic protocols and therapeutic strategies, alongside clinical validation and standardisation, may enhance early detection and personalised care in high-risk pregnancies.

Background/Objectives: The relationship between ultrasound parameters and fetal health in the context of intrauterine growth restriction (IUGR) pregnancies constitutes a significant focus of scholarly research. A comprehensive range of Doppler and echocardiographic evaluations, encompassing the umbilical artery, middle cerebral artery, ductus venosus, uterine arteries, cardiac contractility, ventricular filling, and the thickness of the interventricular septum, has been proposed in pathological pregnancies. Methods: The aim of this paper is to present an examination of these metrics and their implications for fetal health within the framework of IUGR pregnancies and to report a case series in which we analyzed the correlation of these factors. The assessment of these ultrasound indicators can help in better management of the cases in order to obtain better fetal outcomes. Results: Our case study presented dynamics corelated to the after-birth evaluation of the neonate, reflecting the importance of complete ultrasound assessment in high-risk cases. Conclusions: Speckle tracking echocardiography has significantly advanced our understanding of cardiac function in IUGR fetuses. As shown in our cases, it can be used to detect early signs of cardiac dysfunction, differentiating between FGR and SGA.

Personalized digital care in obstetrics: the impact of Heart4Mom® application in the detection and management of severe preeclampsia Managing pregnancy in a patient with Von Willebrand disease: a case report of tailored hemostatic care Management of pregnant women with hereditary and acquired thrombophilia Caesarean myomectomy: controversy, complications and clinical decisions

Background. Preeclampsia, whether de novo or super­im­posed on chronic hypertension, is a major contributor to ma­ter­nal and perinatal morbidity and mortality world­wide. It affects approximately 5% of pregnancies, being closely as­so­cia­ted with fetal growth restriction (FGR), par­ti­cu­larly in early-onset cases. Early identification of high-risk fac­tors and timely intervention remain essential to improve out­comes. Case presentation. We report the case of a preg­nant patient with a history of severe pre­eclamp­sia and FGR in a previous pregnancy, requiring pre­term de­li­very at 27 weeks. In the current pregnancy, early-on­set FGR was diag­nosed at 26 weeks, despite ade­quate an­ti­hyper­ten­sive therapy. The patient was enrolled in a tele­mo­ni­to­­ring pro­gram (Heart4Mom®) from the first tri­mes­ter, ena­bling con­ti­nuous remote blood pressure sur­veil­lance. A hyper­ten­sive crisis (systolic BP ≥ 200 mmHg) was promptly detected through the app, prompting emergency re­fer­ral. Subsequent fetal Doppler evaluation revealed re­versed a-wave in the duc­tus venosus and reduced fetal move­ments, leading to ur­gent delivery. Management and outcomes. The case was managed in accordance with the Romanian Society of Obstetrics and Gynecology and the NICE guidelines. The integration of digital health tools facilitated real-time data collection, early diagnosis, multidisciplinary care, and post­par­tum psychological follow-up. This case is notable for de­mon­stra­ting the successful clinical management of early-on­set preeclampsia without maternal or fetal mortality – an out­come rarely reported in literature, especially in ca­ses diag­nosed prior to 26 weeks. Conclusions. This case high­lights the critical role of telemonitoring platforms, such as Heart4Mom®, in managing high-risk pregnancies. Re­mote sur­veil­lance enables the early detection of clinical de­te­rio­ra­tion, timely therapeutic intervention, and personalized care plan­ning. Future prospective studies are needed to validate these findings and to further integrate digital tools into stan­dard obstetric protocols for hypertensive disorders.