Background: The study aims to investigate the pulp and periapical reaction and healing after capping with EndoSequence Root Repair Material (ERRM) combined with low-level laser application.Methods: In 6 rabbits, pulps were exposed via class V, half of the samples received a low-level diode laser at 980 nm. Thereafter, cavities were capped with regular-set ERRM. The specimens were processed for histomorphological examination after 2 weeks and two months.Results: After 2 weeks, images show mild inflammation and organized odontoblasts in lased group. The non-lased group shows more severe inflammation. The predentin thickness was thicker in the lased group with statistical significance (p < 0.05). After 2 months, inflammatory cells were sparse in both lased and non-lased groups. In the periapical area, group one showed dilated blood vessels and thick fibrous connective tissues. In group two, there were more numerous maturations of PDL fibers with scattered inflammatory cells and congested blood vessel.Conclusions: Using low-level laser therapy in combination with ERRM for pulp capping shortens the inflammatory phase and enhances healing.

Early childhood caries (ECC), one of the most common health problems among children aged six years and below, is considered present when one or more surfaces of a tooth are decayed, missing, or filled. Not only does ECC cause pain for a long time, but it also has short- and long-term health consequences in children. In order to treat ECC, holistic management that includes preventive, restorative, and prosthetic intervention is necessary. This review, a key aspect of which is preventive strategy, stresses the need to lessen the rate of incidence of such conditions as ECC. In case preventive measures do not work, restorative care is considered. The paper discusses all of the available restoration options for paediatric patients. Furthermore, this review includes a detailed analysis of the different types of crowns used in the treatment of ECC, such as stainless-steel crowns (SSCs), resin-composite crowns, and zirconia crowns, and considers their advantages and disadvantages relevant to clinical practice. Overall, this article calls for a well-rounded approach to treating the child’s dental cavity as an emerging progression of ECC. Through this interdisciplinary approach, dentists can significantly enhance oral health among children and help prevent the negative impact of caries on their quality of life.

Background: The relationship between orthodontics and endodontics during the treatment planning phase is scarcely investigated, especially when orthodontic treatment is considered for endodontically treated teeth with apical periodontitis. This systematic review aimed to investigate the effect of orthodontic movement on the periapical healing of teeth that have undergone endodontic root canal treatment/retreatment. Materials and methods: On 15 March 2025, a systematic search was conducted in PubMed, Web of Science Core Collection, EBSCO host and complemented with a manual search of Google Scholar and the gray literature. The quality and the risk of bias of the included studies were assessed using the Joanna Briggs Critical Appraisal tools for human studies and the Systematic Review Centre for Laboratory Animal Experimentation for animal studies. The data about the influence of orthodontic movement on the periapical healing of endodontically treated teeth were extracted and pooled. Results: Out of 4614 identified titles, 6 studies were finally included (two animal and four clinical studies). The risk of bias was high in one study, moderate in three, and low in two. The included animal studies demonstrated a significant delay in the healing process of periapical lesions when orthodontic forces were applied shortly after root canal treatment. However, clinical studies showed no significant impact of orthodontic movement on periapical radiolucency except when the quality of obturation was compromised. Conclusions: Current clinical studies indicate that orthodontic tooth movement does not impair the periapical healing of endodontically treated teeth when the root canal obturation is of adequate quality.

The objective of this study is to assess the calcium ion (Ca²⁺) release, pH shift, bioactivity, and cytotoxicity of both forms of EndoSequence Root Repair Material: regular set (ES) and fast set (ESF). ES (n=10) and ESF (n=10) forms were tested for their bioactivity. Elemental analysis was done on the fresh material and material immersed in phosphate buffered saline (PBS) for 30 days. The surface crystal formation was studied. Cytotoxicity was evaluated at different material concentrations using a human hepatocellular cancer cell line (Huh-7). Both materials contain Ca, P, Ta, Zr, and Si as major elements. Both ES and ESF have a limited percentage of Ytterbium and Neodymium. In the fresh material, the ES had a higher Ca²⁺ concentration with a homogenous surface distribution than ESF. However, ESF released significantly more Ca²⁺ (p<0.05) and had a higher pH over the 7-day course. When the material was immersed in PBS, the ESF exhibited a significantly higher Ca/P ratio of 2.95, while ES had 2.16 Ca/P ratio (p<0.05). The ESF had a greater capacity to precipitate and grow hydroxyapatite (HA) than ES, resulting in more mature crystals forming on the surface. Both SE and ESF demonstrated low cytotoxicity against Huh-7 cells. When ES and ESF were submerged in simulated bodily fluid, both forms produced apatite crystals at the dentin material interface, releasing high Ca²⁺ and displaying a prolonged high pH with high bioactivity potential. Both forms had comparable low cytotoxicity. A higher Ca²⁺ release in ESF indicates dynamic bioactivity, which should be aligned with the clinical requirements.

The literature has reported contradictory findings regarding the association of Intra-radicular posts (IRPs) presence and periapical radiolucent lesions (PRLs) prevalence in endodontically treated teeth (ETT). Considering this, the study aimed to investigate the association between IRPs presence and PRLs prevalence. A cross-sectional study was conducted to compare PRLs prevalence in ETT with and without IRPs. CBCT images were utilized, and the teeth with at least 2 mm of remaining gutta-percha apical to the post-end were included. Two calibrated assessors assessed the PRLs presence. A stepwise backward binomial logistic regression was conducted to evaluate the effect of age, post presence, gender, tooth position (anterior/posterior), and arch location (maxillary/mandibular) on the likelihood of periapical radiolucency presence. The null hypothesis is that the presence of IRPs does not influence the prevalence of PRLs. Teeth with IRPs showed significantly higher PRLs prevalence. However, there were insignificant differences in PRLs prevalence with respect to IRPs type or remaining gutta-percha length. The model, including all five predictors, demonstrated significant fit (χ²(7) = 22.528,p = .002), explaining 14.5% of the variance in the presence of radiolucency (Nagelkerke R²). The Hosmer-Lemeshow test showed no evidence of a lack of fit (χ²(8) = 11.550,p = .172), supporting the model’s adequacy. The model correctly classified 67.3% of cases, with a sensitivity of 54.5%, specificity of 75.4%, positive predictive value (PPV) of 58.3%, and negative predictive value (NPV) of 72.4%. Among the predictors, post presence was the only statistically significant variable (B = 1.300,p < .001,]OR = 3.670,95%CI[1.985–6.785]). A higher prevalence of PRLs was noted among the ETT with IRPs. Within the limitations of this study, we recommend that clinicians should carefully weigh the risks and benefits of using IRPs during the restoration of ETT.