Background: In 2019, a viral and respiratory pathology called COVID-19 emerged in Wuhan, China, and spread to other continents. Its main symptoms include fever, cough, dyspnea, myalgia, anorexia and respiratory distress in the most severe cases, which can lead to death. Furthermore, manifestations in the oral cavity such as ageusia and dysgeusia, as well as lesions in other regions of the oral cavity, can be observed. Main body: This systematic review and meta-analysis aimed to critically assess the clinical evidence on the use of photobiomodulation (PBMT) and antimicrobial photodynamic therapy (aPDT) for the treatment of oral lesions in patients infected with Sars-Cov-2. The literature extracted from electronic databases such as PubMed, Medline, CINAHL, and Google Scholar was screened for eligibility, and relevant articles were included. The review is limited to manuscripts published in English, Spanish and Portuguese language between December 2019 and October 2021. A total of 5 articles with 11 cases retracting PBMT and aPDT as therapeutic strategies for the regression of oral lesions and painful symptoms. The results show favoring the associated use of PBMT with aPDT (P = 0.004), and the isolated use of PBMT with the result of significant “P = 0.005” and good confidence interval (7.18, 39.20) in ulcerative lesions, herpetic, aphthous, erythematous, petechiae and necrotic areas. Conclusions: PBMT and aPDT could be effective in the treatment of oral lesions of patients infected with Sars-Cov-2 in a short period of time; however, more long-term randomized clinical trials studies are needed to define the therapeutic strategy.

Objective: To assess the impact of intravascular laser irradiation of blood (ILIB) on the primitive carotid artery (PCA) hemodynamic variables, specifically blood pressure (BP) and heart rate (HR), in mastectomized patients undergoing hormone blocker treatments. Materials and methods: This study is a controlled, experimental, and randomized clinical trial. Patients were allocated into two groups: the experimental group (G1)-patients who received ILIB therapy using a 660 nm laser targeted at the PCA, and the control group (G2)-patients who did not receive ILIB therapy. Clinical research was conducted weekly, with measurements of systolic blood pressure (SBP), diastolic blood pressure (DBP), and HR. The Mann-Whitney U test for independent samples was used, with a significance level of α = 0.05. Results: Systemic photobiomodulation on the PCA did not demonstrate a statistically significant difference in relation to SBP and DBP. However, for HR, the p-value was decreased from 142.3 to 116.4 mmHg in G1, and from 130.4 to 119.8 mmHg in G2. The DBP varied from 78.8 to 72.8 mmHg in G1, and from 79.1 to 74.2 mmHg in G2. A statistically significant difference was observed in HR, decreasing from 81.3 to 62.06 bpm in G1, and changing minimally from 74.1 to 75.1 bpm in G2. A considerable reduction was present in the timing of application. Conclusions: ILIB therapy applied to the PCA induces a reduction in BP and, more notably, HR in mastectomized women using the tamoxifen or aromatase inhibitors.

The purpose of this study is to categorize a transdermal anatomical location in the Primitive Carotid Artery (Common) for the use of modified Intrasvacular LASER Irradiation of Blood (ILIB). This study was conducted in twelve patients undergoing hormone blockers - Anastrozole / six and Tamoxifen / six and five patients without hormone therapy, all of which were performed in patients currently undergoing disease control therapy, where the site primary neoplastic were the mammary ducts (uni or bilateral). The noninvasive therapy of systemic LASER in the cervical region was motivated by the biological, technical and functional inactivity guided by the INCA (National Cancer Institute - Brazil) in order to avoid any manipulations on the same side of the operated breast, specifically the arm, due to to the possibilities of undesirable intercurrences that may cause clinical lowering and laboratory markers during the multidisciplinary treatment. Cancer patients treated with personalized protocols associated with the carotid region reduce the health-disease process related to morbidities as a consequence of the dysgeusias and imbalance of the oral microbiome. Adding to these benefits of photoenteral therapy (ILIB modified), systemic ones, promoted by the bifurcation of the primitive carotid artery in internal and external, triggering a homeostatic hormonal balance and vascularization of the anterior region of the face, correspondingly.

Introduction and importance: Bisphosphonates are drugs that have demonstrated effectiveness in the prevention and treatment of bone metastases from malignant neoplasms and other diseases of bone metabolism and although they represent a risk factor for osteonecrosis. Presentation of case: The present case depicts a patient with prostate neoplasia and metastases, referred to the dental department because he presented severe periodontal infection in the previous incisors of the mandible and was under treatment by intravenous zoledronic acid. A panoramic x-ray showed a marked bone loss with a periodontal infection that indicated the tooth exodontia of the affected teeth. However, 2 months after the removal of the dental elements, bone sequestration was detected a CT scan confirmed that. Surgery was then performed to remove mandibular bone sequestration and photodynamic therapy (aPDT) treatment for decontamination of the affected area. Discussion: There was a tissue reconstitution of the site in 3 weeks and total eradication of bone necrosis with aPDT treatment associated with bone sequestration. Conclusion: aPDT has proven to be an effective complementary treatment for the process of tissue decontamination and photostimulation in cases of BRONJ. Highlights:

Introduction: In 2019, a viral and respiratory pathology called COVID-19 emerged in Wuhan, China and spread to other continents. Its main symptoms include fever, cough, dyspnea, myalgia, anorexia and respiratory distress in the most severe cases, which can lead to death. Furthermore, manifestations in the oral cavity such as ageusia and dysgeusia, as well as lesions in other regions of the oral cavity, can be observed.Objective: Are Photobiomodulation (PBM) and Antimicrobial Photodynamic Therapy (aPDT) effective to treat oral manifestations of patients infected with SARS-CoV-2?Methodology: It was defined following the PRISMA guidelines (Preferred Report on Systematic Reviews and Meta-Analysis), and registered in the database in the International Prospective Registry of Systematic Reviews (PROSPERO), including articles published between December 2019 to May 2021, Independent reviewers selected studies, qualitatively extracted data, assessed risk of bias using the Joanna Briggs Institute, assessed certainty of evidence through meta-analysis.Results: Of the 5,959 articles found, 32 fit the types of studies, but only 5 of them attended the pre-established criteria. Data corresponding to the articles, protocols used and clinical outcome were extracted, then submitted to qualitative and descriptive analysis. The results show favoring the associated use of PBMT with aPDT (p=0.004), and the isolated use of PBMT with the result of significant “p=0.005” and good confidence interval (7.18, 39.20) in ulcerative lesions, herpetic, aphthous, erythematous, petechiae and necrotic areas.Conclusion: According to the articles included in this review, PBMT and aPDT were effective in the treatment of oral lesions of patients infected with COVID-19 in a short period of time.