The study presents the economic feasibility assessment of converting the produced biogas from water hyacinth biomass into electricity. Approximately, 0.3793 m³CH₄/kgVS was generated from the water hyacinth biomass. The research indicated that the available water hyacinth population on the Lower Volta River in the year 2020 could potentially generate a methane yield of 53.676 × 10⁶m³. The volume of methane gas generated had the potential to produce an annual electricity output of 110.792 × 10⁶ kWh, which could be integrated into the national grid. The economic analysis indicated positive results with an initial total investment cost of $67,273,700. The project showed a positive net present value (NPV) of $8,923,769 and a levelized cost of 0.172 $/kWh. The simple payback and equity payback periods were determined to be 5.5 and 11.3 years, respectively. Furthermore, a sensitivity analysis conducted showed that the project’s NPV remained positive when variations in input parameters such as initial cost, operations, and maintenance cost were less than 15% sensitive range. However, a 30% reduction in the feed-in tariff cost resulted in a negative NPV. In conclusion, biogas production from water hyacinth biomass in Ghana can make a significant contribution to the country’s energy mix and help alleviate the energy shortfall in rural areas.