Healthcare 5.0 represents the next evolution in intelligent and interconnected healthcare systems, leveraging emerging technologies such as Artificial Intelligence (AI) and the Internet of Medical Things (IoMT) to enhance patient care and automation. While Intrusion Detection Systems (IDSs) are a critical component for securing these environments, the current literature lacks a systematic analysis that jointly evaluates the effectiveness of AI models, the suitability of datasets, and the role of Explainable Artificial Intelligence (XAI) in the Healthcare 5.0 landscape. To fill this gap, this survey provides a comprehensive review of IDSs for Healthcare 5.0, analyzing state-of-the-art approaches and available datasets. Furthermore, a practical case study is presented, demonstrating that the fusion of network and biomedical features significantly improves threat detection, with physiological signals proving crucial for identifying complex attacks like spoofing. The primary contribution is therefore an integrated analysis that bridges the gap between cybersecurity theory and clinical practice, offering a guide for researchers and practitioners aiming to develop more secure, transparent, and patient-centric systems.

Healthcare 5.0 integrates Artificial Intelligence (AI), the Internet of Things (IoT), real-time monitoring, and human-centered design toward personalized medicine and predictive diagnostics. However, the increasing reliance on interconnected medical technologies exposes them to cyber threats. Meanwhile, current AI-driven cybersecurity models often neglect biomedical data, limiting their effectiveness and interpretability. This study addresses this gap by applying eXplainable AI (XAI) to a Healthcare 5.0 dataset that integrates network traffic and biomedical sensor data. Classification outputs indicate that XGBoost achieved 99% F1-score for benign and data alteration, and 81% for spoofing. Explainability findings reveal that network data play a dominant role in intrusion detection whereas biomedical features contributed to spoofing detection, with temperature reaching a Shapley values magnitude of 0.37.

Healthcare 5.0 integrates Artificial Intelligence (AI), the Internet of Things (IoT), real-time monitoring, and human-centered design toward personalized medicine and predictive diagnostics. However, the increasing reliance on interconnected medical technologies exposes them to cyber threats. Meanwhile, current AI-driven cybersecurity models often neglect biomedical data, limiting their effectiveness and interpretability. This study addresses this gap by applying eXplainable AI (XAI) to a Healthcare 5.0 dataset that integrates network traffic and biomedical sensor data. Classification outputs indicate that XGBoost achieved 99% F1-score for benign and data alteration, and 81% for spoofing. Explainability findings reveal that network data play a dominant role in intrusion detection whereas biomedical features contributed to spoofing detection, with temperature reaching a Shapley values magnitude of 0.37.