Obesity-mediated inflammation represents a key connection between the intake of foods with high inflammatory potential and colorectal cancer (CRC) risk. We aimed to explore the association between energy-adjusted dietary inflammatory index (E-DII) in relation to CRC risk in both obese and non-obese subjects. This study included 99 histopathologically confirmed CRC cases, 73 colonic polyps cases, and 141 healthy controls from tertiary medical centres in both urban and suburban areas in Peninsular Malaysia. The subjects were categorised into body mass index (BMI) < 25 kg/m² and BMI ≥ 25 kg/m² groups. E-DII scores were computed based on dietary intake assessed using a validated food frequency questionnaire (FFQ). Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for potential cofounders. The mean dietary energy intake and mean BMI values of the subjects tended to increase as the E-DII scores increased (p for trend < 0.001). E-DII was significantly related to CRC risk only in obese subjects (OR = 1.45; 95% CI = 1.30–1.77; p < 0.001 for trend). Stratified analyses of risk factors showed significant associations between E-DII and CRC risk by age group (p for interaction = 0.030), smoking status (p for interaction = 0.043), and anthropometric indices for both males and females (p for interaction < 0.001) in the most pro-inflammatory E-DII quartile vs. the lowest E-DII quartile. Overall, pro-inflammatory diets were associated with an increased incidence of CRC in the Malaysian population, particularly in obese subjects.

Background: Quality of life (QoL) is a crucial outcome measure in cancer care. This study aimed to identify the association of health-related quality of life (HRQoL) among colorectal cancer (CRC) patients in Malaysia. Methods: The study was conducted from January 2021 to July 2022, recruiting CRC patients from two teaching hospitals in Malaysia. The validated Malay versions of EORTC QLQ-C30 and QLQ-CR29 questionnaires assessed physical, psychological, and social functioning. Patients were evaluated 6 months after diagnosis to determine QoL associations. Anthropometric measurements were recorded at baseline (diagnosis, 0 months) and at follow-up (6 months). Results: Among 87 CRC patients (55.2% male, mean age 59.8 ± 11.8 years), 37.9% had stage III disease and 13.8% had stage IV. Most patients (93%) underwent surgery and 78% received chemotherapy. The mean global health status score was 66.57 ± 20.75. Multiple linear regression analysis revealed that older age (p = 0.03), advanced cancer stage (p = 0.017), lower body weight (p = 0.017), and reduced hip circumference (p = 0.040) are significantly associated with poorer global health status quality of life (GHS QoL). Nutritional parameters specifically predicted functional domains: lower body weight and BMI predicted role and cognitive function, while lower hip circumference predicted emotional function. Conclusions: Advanced age, disease stage, and nutritional status are significant associations of QoL in Malaysian CRC patients. These findings highlight the importance of nutritional assessment and intervention in CRC survivorship care to optimize patient outcomes.

Background: Quality of life (QoL) is a crucial outcome measure in cancer care. This study aimed to identify predictors of health-related quality of life (HRQoL) among colorectal cancer (CRC) patients in Malaysia. Methods: The study was conducted from January 2021 to July 2022, recruiting CRC patients from two teaching hospitals in Malaysia. The validated Malay versions of EORTC QLQ-C30 and QLQ-CR29 questionnaires assessed physical, psychological, and social functioning. Patients were evaluated at 6 months post-treatment to determine QoL predictors. Results: Among 87 CRC patients (55.2% male, mean age 59.8±11.8 years), 37.9% had stage III disease and 13.8% had stage IV. Most patients (93%) underwent surgery and 78% received chemotherapy. The mean Global Health Status score was 66.57±20.75. Multivariate analysis revealed that older age (p = 0.03), advanced cancer stage (p = 0.017), lower body weight (p = 0.017), and reduced hip circumference (p = 0.040) significantly predicted poorer QoL. Nutritional parameters specifically predicted functional domains: lower body weight and BMI predicted role and cognitive function, while lower hip circumference predicted emotional function. Conclusions: Advanced age, disease stage, and nutritional status are significant predictors of QoL in Malaysian CRC patients. These findings highlight the importance of nutritional assessment and intervention in CRC survivorship care to optimize patient outcomes.