Objective: The basis for current and future lung cancer immunotherapy depends on our knowledge of molecular mechanisms of interactions between tumor and immune system cells. Interactions that occur between different intratumoral populations of the same cells are important. In our study, we aimed to evaluate relationship between the clinical and prognostic features and T lymphocyte subgroups of patients with lung tumors after neoadjuvant treatment. Methods: A total of 72 patients were included in our study, including study group, 39 of whom received neoadjuvant chemotherapy. Clinical/radiological/pathological findings of patients and CD4/CD8 staining rates in peritumoral/intratumoral areas were recorded. Results: Our study revealed significantly lower intratumoral CD4 + T cell density and lower intratumoral CD4/CD8 ratio in primary tumor after neoadjuvant therapy (respectively, 0.012 and 0.016). Considering tumor types, when control-study groups were compared, inflammation was statistically significant only in adenocarcinoma subtype; intratumoral CD4/CD8 ratio was statistically significant only in squamous-cell carcinoma subtype (respectively, p = 0.0008 and p = 0.0139). When CD4 + T lymphocytes and CD8 + T lymphocytes and CD4/CD8 ratio were compared between control and study groups in low-stage patients according to clinical stages, only intratumoral CD4 + T lymphocyte values and intratumoral CD4/CD8 ratio were significant (respectively, p = 0.0291 ve p = 0.0154). Conclusion: All cell types of innate and adaptive intratumoral immunity can affect lung cancer tissues simultaneously, and these interactions have a very complex structure. Understanding the tumor microenvironment and the different roles of associated cancer immune cells may lead to the discovery of new targets for immunological therapies and increased survival times in lung cancer.

Foreign body aspirations are a serious respiratory condition that can threaten life, particularly in childhood, in the first three years of life. In our article, the approach observed in physicians who face foreign body aspirations in the pediatric age group are analyzed and the approach proposed in these cases are discussed under the current literature and relevant legal regulations.

Foreign body aspirations and esophageal foreign bodies are life-threatening conditions. Sometimes they or their complications can cause severe morbidity and even mortality. Their exact incidence is unknown. Foreign body aspirations and esophageal foreign bodies are most commonly observed in the pediatric age group. While interventions are generally required for the removal of respiratory tract foreign bodies, the majority of esophageal foreign bodies come out spontaneously. Removal of foreign bodies that block the lumen of the organ to a great extent, react with the mucosa such as battery magnets, and can cause poisoning, sharp-edged objects, and swellable foreign bodies such as legumes, should be done acutely. In the removal of foreign bodies, endoscopic methods (flexible/rigid bronchoscope) are used in the respiratory system. Other methods used in esophageal foreign bodies are follow-up and pushing and pulling maneuvers with equipment, and at times, open surgical procedures can be applied. The success of the procedures is high, and patients can be discharged in the early postoperative period. Their incidence can be decreased by raising awareness on the subject, parents can be prevented from making wrong applications in these cases, and clinicians can keep these conditions in mind in differential diagnosis. In this article, the clinical features and diagnosis and treatment methods of foreign body aspiration and esophageal foreign bodies will be discussed separately.

Objectives: Traumatic iatrogenic pneumothorax occurs most often after a transthoracic needle biopsy. Since this procedure has become a common outpatient intervention, emergency department admissions of post-biopsy pneumothorax patients have increased. The aim of this study was to determine the factors that predict the need for tube thoracostomy in patients with post-biopsy pneumothorax in the emergency department. Methods: A retrospective cross-sectional study was conducted on 191 patients with post-biopsy pneumothorax who were admitted to the emergency department between 2010 and 2017. Patient characteristics, clinical findings at the emergency department presentation, and procedural and radiological features were reviewed. A multivariate logistic regression model was constructed using the variables from univariate comparisons to determine the need for tube thoracostomy in patients with iatrogenic pneumothorax, and the effect sizes were demonstrated with odds ratios. Results: Tube thoracostomies were performed on 69 out of 191 patients (36.1%). A total of 122 patients (63.9%) were treated with supplemental oxygen therapy without any other intervention, and 126 patients (66.0%) were hospitalized. In the multivariate model, the variables predicting the need for a tube thoracostomy were decreased breath sounds, dyspnea, decreased systolic blood pressure, decreased oxygen saturation and increased pleura-lesion distance. A distance of 19.7mm predicted the need with a sensitivity of 69.6% and a specificity of 62.3%. Conclusion: Decreased breath sounds, dyspnea, decreased systolic blood pressure, decreased oxygen saturation, and increased pleura-lesion distance may predict the need for a tube thoracostomy in patients with post-biopsy pneumothorax. Copyright (c) 2018 The Emergency Medicine Association of Turkey. Production and hosting by Elsevier B.V. on behalf of the Owner. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Objective: Lung hydatid cyst is an infectious disease caused by the parasite Echinococcus granulosus. Surgery is the main treatment of the disease in lung hydatid cysts. In our article, we aimed to share our experiences with our patients who underwent surgical treatment for hydatid cysts of the lungs. Methods: The data of 41 patients who underwent surgical treatment for pulmonary hydatid cysts in our clinic were analyzed retrospectively. The factors affecting the success of surgical treatment were analyzed. Results: Eighteen (43.9%) of the patients were male and 23 (56.1%) were female. There was no statistically significant difference between the size groups in terms of length of hospital stay (p=0.070). No statistically significant correlation was found between the number of lesions and postoperative complications (p=0.367). Conclusion: Lung hydatid cysts are a public health problem that can be seen in all age groups. Although different symptoms and complications related to the disease are encountered in lung hydatid cysts, surgery is an effective treatment method with low recurrence, morbidity and mortality.

Background: In this study, we aimed to investigate the effectiveness of isolated rigid bronchoscopy used in the treatment of postintubation tracheal stenosis by its relationship with the most frequently used classifications, our own classification Stenosis Index, stenosis dimensions and its combinations. Methods: Between March 2010 and July 2020, a total of 39 patients (16 males, 23 females; mean age: 41.5±20.7 years; range, 15 to 72 years) who had isolated rigid bronchoscopic dilation as a result of postintubation tracheal stenosis were retrospectively analyzed. The duration of treatment, the number of procedures, and the success of the treatment of patients were analyzed according to the most frequently used classifications and compared to our new classification. Results: A statistically significant difference was found between the Stenosis Index groups in terms of the number of procedures and duration of treatment (p<0.01, p<0.01, respectively). No statistically significant differences were observed among the most frequently used classifications in terms of number of procedures and duration of treatment. The Stenosis Index classification groups most consistently reflected the success rate of the procedure, the number of procedures, the duration of the treatment and the rate of patients resected. Conclusion: The Stenosis Index classification was considered to be a more effective parameter than the most frequently used classifications on the decision to give the patients with postintubation tracheal stenosis a chance to treat with bronchoscopic dilations procedure before resection.