Prof. Javed Musarrat

Co-authors

Following

Followers

Research Focus & Metrics

Explore full metrics on Scilit

Academic Career Length

39Years (1988-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications

1 August 2006 in Chemosphere

Journal Article

Significance of Bacillus subtilis strain SJ-101 as a bioinoculant for concurrent plant growth promotion and nickel accumulation in Brassica juncea

Sabina Zaidi

Saima Usmani

Braj Raj Singh

Javed Musarrat

1 January 2013 in Journal of Pharmacy and Bioallied Sciences

Journal Article

Chitinases: An update

Saleem Javed

Rifat Hamid

MinhajA Khan

Mahboob Ahmad

Malik Mobeen Ahmad

Javed Musarrat

Chitin, the second most abundant polysaccharide in nature after cellulose, is found in the exoskeleton of insects, fungi, yeast, and algae, and in the internal structures of other vertebrates. Chitinases are enzymes that degrade chitin. Chitinases contribute to the generation of carbon and nitrogen in the ecosystem. Chitin and chitinolytic enzymes are gaining importance for their biotechnological applications, especially the chitinases exploited in agriculture fields to control pathogens. Chitinases have a use in human health care, especially in human diseases like asthma. Chitinases have wide-ranging applications including the preparation of pharmaceutically important chitooligosaccharides and N-acetyl D glucosamine, preparation of single-cell protein, isolation of protoplasts from fungi and yeast, control of pathogenic fungi, treatment of chitinous waste, mosquito control and morphogenesis, etc. In this review, the various types of chitinases and the chitinases found in different organisms such as bacteria, plants, fungi, and mammals are discussed.

1 June 2016 in Journal of Colloid and Interface Science

Journal Article

Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates

Ameer Azam

Mansour S. Al-Said

17 November 2014 in PLOS ONE

Journal Article

Reactive Oxygen Species Mediated Bacterial Biofilm Inhibition via Zinc Oxide Nanoparticles and Their Statistical Determination

Abdulaziz Al-Khedhairy

The formation of bacterial biofilm is a major challenge in clinical applications. The main aim of this study is to describe the synthesis, characterization and biocidal potential of zinc oxide nanoparticles (NPs) against bacterial strain Pseudomonas aeruginosa. These nanoparticles were synthesized via soft chemical solution process in a very short time and their structural properties have been investigated in detail by using X-ray diffraction and transmission electron microscopy measurements. In this work, the potential of synthesized ZnO-NPs (∼10–15 nm) has been assessed in-vitro inhibition of bacteria and the formation of their biofilms was observed using the tissue culture plate assays. The crystal violet staining on biofilm formation and its optical density revealed the effect on biofilm inhibition. The NPs at a concentration of 100 µg/mL significantly inhibited the growth of bacteria and biofilm formation. The biofilm inhibition by ZnO-NPs was also confirmed via bio-transmission electron microscopy (Bio-TEM). The Bio-TEM analysis of ZnO-NPs treated bacteria confirmed the deformation and damage of cells. The bacterial growth in presence of NPs concluded the bactericidal ability of NPs in a concentration dependent manner. It has been speculated that the antibacterial activity of NPs as a surface coating material, could be a feasible approach for controlling the pathogens. Additionally, the obtained bacterial solution data is also in agreement with the results from statistical analytical methods.

5 August 2013 in PLOS ONE

Journal Article

Copper Oxide Nanoparticles Induced Mitochondria Mediated Apoptosis in Human Hepatocarcinoma Cells

Maqsood Ahmed Siddiqui

Hisham Alhadlaq

Javed Ahmad

Abdulaziz Al-Khedhairy

Javed Musarrat

Maqusood Ahamed

Copper oxide nanoparticles (CuO NPs) are heavily utilized in semiconductor devices, gas sensor, batteries, solar energy converter, microelectronics and heat transfer fluids. It has been reported that liver is one of the target organs for nanoparticles after they gain entry into the body through any of the possible routes. Recent studies have shown cytotoxic response of CuO NPs in liver cells. However, the underlying mechanism of apoptosis in liver cells due to CuO NPs exposure is largely lacking. We explored the possible mechanisms of apoptosis induced by CuO NPs in human hepatocellular carcinoma HepG2 cells. Prepared CuO NPs were spherical in shape with a smooth surface and had an average diameter of 22 nm. CuO NPs (concentration range 2–50 µg/ml) were found to induce cytotoxicity in HepG2 cells in dose-dependent manner, which was likely to be mediated through reactive oxygen species generation and oxidative stress. Tumor suppressor gene p53 and apoptotic gene caspase-3 were up-regulated due to CuO NPs exposure. Decrease in mitochondrial membrane potential with a concomitant increase in the gene expression of bax/bcl2 ratio suggested that mitochondria mediated pathway involved in CuO NPs induced apoptosis. This study has provided valuable insights into the possible mechanism of apoptosis caused by CuO NPs at in vitro level. Underlying mechanism(s) of apoptosis due to CuO NPs exposure should be further invested at in vivo level.

1 April 2013 in Journal of Hazardous Materials

Journal Article

Phytotoxic hazards of NiO-nanoparticles in tomato: A study on mechanism of cell death

Mohammad Faisal

Quaiser Saquib

Abdulrahman A. Alatar

Abdulaziz Al-Khedhairy

Ahmad K. Hegazy

Javed Musarrat

About Me

Prof. Javed Musarrat has been serving as the Vice-Chancellor of Integral University, Lucknow, since 2021, an institution accredited with an NAAC A+ grade, and recognized under sections 2(f) and 12(B) of the UGC Act, 1956. Previously, he served as the Vice-Chancellor of Baba Ghulam Shah Badshah University (BGSBU), Rajouri, a State University, Jammu and Kashmir, India, from 2015 to 2020. Prof. Musarrat earned his Ph.D. in Biochemistry from Aligarh Muslim University (AMU) in 1986. Over a distinguished career spanning more than three decades at AMU, he held several key positions, including Full Professor of Microbiology in the Department of Agricultural Microbiology, Chairman of the Department of Agricultural Microbiology, and Dean of the Faculty of Agricultural Sciences. He also held important administrative roles such as Registrar, Officer on Special Duty (Development), and Officiating Vice-Chancellor of AMU. Internationally renowned for his contributions to Molecular Microbiology and Nanotoxicology, Prof. Musarrat has published more than 200 research papers in high-impact, Web of Science, and Scopus-indexed journals. He is also an accomplished author, with six (06) books published by Springer (Netherlands/USA) and 23 book chapters. Additionally, he holds a US patent and has deposited over 100 DNA sequences in the International Depository (NCBI-GenBank, USA). He is consistently featured on Stanford University's list of the Top 2% of Scientists globally, with over 16,000 citati

Prof. Javed Musarrat

Prof. Javed Musarrat

Research Focus & Metrics

Academic Career Length

Publication Type Breakdown

Representative Publications

About Me