Mesenchymal chondrosarcoma (MCS) is characterised by small round cell biology, frequent HEY1-NCOA2 fusion, and high vascularity. These features plausibly lessen extracellular matrix barriers and confer relative chemosensitivity. We synthesised peri-operative (preoperative/neoadjuvant; postoperative/adjuvant) and palliative chemotherapy outcomes separately across multiple cohorts and case reports as well as the summarised the guidelines (ESMO/NCCN) In localised disease, integrating multi-agent Ewing-type chemotherapy with complete resection is associated with improved disease control. Contemporary 5-year overall survival (OS) typically spans ~55–73% across studies, while event-free survival (EFS) gains are demonstrated more consistently than OS gains in pooled analyses. In advanced MCS, first-line polychemotherapy yields modest, non-curative activity, with objective response rates (ORRs) of ~25–35% in adults, median progression-free survival (PFS) of ~4.7–6.7 months, and median OS of ~18 months. Activity may be higher in younger patients and for platinum–anthracycline combinations. We also discussed emerging therapies. Trabectedin demonstrates low disease control rate in translocation-related sarcomas, including few MCS cases. Anti-angiogenic tyrosine kinase inhibitors, such as apatinib and pazopanib, demonstrate activity in chondrosarcoma, but MCS-specific data are lacking. IDH1 inhibition benefits conventional subtypes rather than MCS. Early immunotherapy experience is limited, but pathway-directed strategies targeting BCL2 and PI3K-mTOR warrant evaluation.

Introduction and Objective: Voyeurism is characterized by recurrent and intense sexual arousal derived from observing unsuspecting individuals who are naked, disrobing, or engaging in sexual activity. Suggested risk factors for developing voyeurism include childhood sexual abuse, substance misuse, hypersexuality, emotional dysregulation, poor mental health, maladaptive coping strategies, and external pressures The aim of this publication is to discuss various aspects of voyeurism based on the latest literature.Review Methods: The PubMed database was searched to find scientific articles in which the terms “voyeurism” or “voyeuristic” appear in the title, abstract, or keywords.Brief Description of the State of Knowledge: Estimating the global prevalence of voyeurism is challenging due to inconsistent data, with reported rates ranging from over 10% to approximately 30–40%. Studies consistently indicate that voyeuristic behavior is more common among men. It often exhibits a compulsive and repetitive nature and can serve as a precursor to other sexual crimes, such as sexual sadism or pedophilia. Treatment primarily involves cognitive behavioral therapy (CBT), with pharmacological support using SSRIs like fluoxetine and paroxetine, showing effectiveness. Summary: The authors highlight the importance of further exploration into this topic and emphasize the need for a more accurate understanding of voyeurism's prevalence in the general population, as current data may be inconclusive.

Couvade syndrome occurs when expectant fathers experience psychological and somatic symptoms typical of pregnancy. Common somatic symptoms include gastrointestinal problems, toothache, heartburn, fatigue and back pain, while anxiety is the most commonly reported psychological symptom. Symptoms typically manifest during the first trimester of the partner’s pregnancy, decrease or disappear during the second trimester, increase during the third trimester, and usually resolve after delivery. The aetiology of Couvade’s syndrome remains unclear, with psychoanalytic theories suggesting paternal anxiety and feelings of marginalisation. Hormonal changes, including increased cortisol, estradiol, prolactin and decreased testosterone levels during the third trimester, are also thought to be contributing factors. The prevalence varies widely, from 11% to 97%, depending on the population studied. Despite its reported prevalence, research into Couvade’s syndrome is limited, especially studies involving closely related women with similar symptoms. The findings highlight the need for further research to better understand this phenomenon and its impact on family dynamics during pregnancy.

Pornography is most commonly defined as any depiction of sexual behaviours aimed at inducing sexual arousal. According to numerous scientific studies, the use of pornography is a widespread phenomenon across all age groups today, with a particularly high prevalence among men. The popularity of pornographic content seems to be increasing over the years, primarily due to its easy accessibility, which stems mainly from technological advancements. Given that pornography addiction is not formally classified in DSM-5 or ICD-10, most studies assessing the frequency of this phenomenon are based on the subjective impressions of participants, suggesting that the issue affects a few to several percent of the population. It has also been observed that pornography addiction shows strong similarities to addiction to psychoactive substances. Motivations for consuming pornography are linked to evolutionary mechanisms, sexual and life strategy theories, and psychological models. Most users of pornographic materials state that they view them to satisfy sexual urges, which is more pronounced among men. Notably, both genders report using pornography equally often to improve their sexual performance. The impact of pornography on its users has not been clearly classified as either positive or negative due to significant discrepancies in research findings. Some studies suggest that it negatively affects male sexual functioning, while positively influencing female sexual experience.

Introduction and objective: Consensual non-monogamy (CNM) refers to various relationship types in which at least one partner, with the other’s consent, forms sexual and/or emotional connections with other people. In open relationships, partners are allowed to engage sexually with others, but emotional intimacy is reserved for the primary relationship, which takes precedence. The aim of this article is to gather the most up-to-date information on open relationships.Material and methods: A review of studies available on the PubMed platform (https://pubmed.ncbi.nlm.nih.gov/) was conducted, including articles with free full-text access that used the keywords: “open relationship”, “CNM” and "Consensual non-monogamy."Brief Description of the State of Knowledge: CNM includes open relationships, polyamory, polyfidelity, and swinging. Interest in open relationships has increased in recent years, with more people expressing curiosity about them than those actively participating. Men, individuals with high cognitive empathy, those less prone to jealousy, and those capable of experiencing compersion—the joy from a partner’s involvement with others—are particularly interested in open relationships. Summary: Research suggests potential benefits of CNM, including greater relationship and sexual satisfaction compared to monogamous arrangements. However, open relationships can also pose challenges such as social stigma, the potential breakdown of the primary relationship, or complications in parenting for those involved. Despite growing interest, CNM and phenomena like compersion remain under-researched, providing an open field for further investigation into their dynamics and impact on individual and relational well-being.