Background: Meningiomas are common central nervous system neoplasms, accounts for 30% of all primary intracranial neoplasms; the occurrence of meningiomas with cystic lesions is an exceptionally rare. Lymphoplasmacyte-rich meningioma (LPRM) is a rare pathological entity belong to the World Health Organization Grade I meningiomas. LPRM is characterized by abundant lymphoplasmacytic infiltrates which over-shadow the underlying meningothelial component. Case Description: A 42-year-old male was admitted to our hospital with a chronic headache for about 3 weeks prior to admission. His symptoms worsen, and subsequently, he experienced left extremities weakness about 1 week before admission. His brain magnetic resonance imaging revealed an irregular and heterogeneously enhancing solid lesion with intratumoral cystic changes at the temporal lobe. A gross total resection was performed; pathological examination revealed a cystic LPRM. Conclusion: This rare variant of meningioma is a benign tumor entity featured with massive inflammatory cell infiltration and often less proportion of meningothelial elements. Surgical resection remains the treatment of choice. This is the first report regarding cystic LPRM from Indonesia; we also summarized relevant literature upto-date, May 2020, reported LPRM cases.

Malignant peripheral nerve sheath tumors (MPNSTs) constitute a group of soft tissue neoplasm with neuroectodermal origin. Most cases are small at presentation and only some have been described reaching giant dimensions. We report two cases that were diagnosed and treated as giant MPNST of the scalp. Both patients had extensive lesion on the head with intracranial infiltration. Microsurgical resection was indicated and a vascularized free flap was used to cover the defect. During follow-up the tumors recurred and further surgical excision treatment by adjuvant radiation therapy was performed. MPNSTs of the scalp are rare neoplasm of the peripheral nervous system. They are aggressive lesion that can recur and their management requires a multimodality approach.

Background: Brain metastases are a common complication in a wide range of cancers but are ubiquitous among patients with lung cancer. Limited data are available on the survival of patients with lung cancer and brain metastases in Indonesia. In this study, we aimed to identify the factors that might contribute to and predict survival in patients with non–small cell lung cancer (NSCLC) that resulted in brain metastases. Methods: This retrospective study on patients with NSCLC and brain metastases was conducted using data available from the medical records of the Dharmais National Cancer Hospital, Jakarta, Indonesia. The study outcome was survival time, which was associated with sex, age, smoking status, body mass index, number of brain metastases, tumor location, systemic therapy, and other therapies. Descriptive statistics, median survival, Kaplan-Meier graphs, and Cox regression were analyzed using SPSS version 27. Results: We included 111 patients with NSCLC and brain metastases in this study. The median patient age was 58 years. Long survivorship was observed among women (median: 95.4 weeks; P < .0003), patients with epidermal growth factor receptor (EGFR) mutations (median: 41.8 weeks; P < .0492), those who received chemotherapy (median: 58 weeks; P < .000), and those who received a combination of surgery and whole brain radiotherapy (WBRT; median: 64.7 weeks; P = .0174). Multivariate analysis showed consistent results for the following factors: sex, EGFR mutations, systemic therapy, and surgery plus WBRT. Conclusions: Female sex and EGFR mutations in patients with NSCLC and brain metastases are associated with a high survival rate. Patients who have NSCLC with brain metastases will benefit from treatment with EGFR tyrosine kinase inhibitors, chemotherapy, and surgery plus WBRT.

Nutrisi merupakan faktor pendukung bagi pertumbuhan dan perkembangan anak usia bawah lima tahun (balita). Kondisi kekurangan gizi pada balita dapat disebabkan oleh praktik pemberian asupan makan yang kurang tepat (inappropriate feeding practices). Makanan pendamping air susu ibu (MPASI ) adalah makanan padat dan cair yang diberikan bersama dengan ASI ketika pemenuhan kecukupan gizi yang semakin meningkat seiring bertambahnya usia bayi. Penelitian ini bertujuan untuk mengetahui pengaruh edukasi dengan media cetak booklet terhadap pengetahuan ibu dalam pemberian MPASI pada bayi. Desain penelitian yang digunakan adalah pre-experimental design dengan menggunakan rancangan penelitian one group pretest-posttest design. Populasi penelitian adalah ibu yang mempunyai anak usia 4-8 bulan di wilayah kerja Puskesmas Gang Sehat dan Puskesmas Purnama di Kecamatan Pontianak Selatan. Subjek penelitian diambil secara consecutive sampling dengan jumlah responden sebanyak 75 ibu. Analisis bivariat pengetahuan menggunakan Wilcoxon. Skor pengetahuan sebelum diberikan edukasi MPASI adalah 75,98 lalu meningkat sebesar 82,08 setelah pemberian edukasi. Sejumlah 70% ibu mengalami peningkatan kategori menjadi baik pada skor pengetahuan MPASI. Hasil uji Wilcoxon diperoleh nilai p = 0,00 (sig < 0,05). Kesimpulan penelitian ini bahwa terdapat peningkatan rerata skor pengetahuan dan kategori pengetahuan setelah diberikan edukasi kesehatan.

Salah satu penyebab nyeri kepala yang paling mengganggu adalah migrain. Keluhan ini dapat memengaruhi kehidupan pribadi dan sosioekonomi penderitanya. Sakit kepala bersama dengan gejala lain adalah ciri sindrom klinis yang dikenal sebagai migrain tanpa aura. Mahasiswa kedokteran berisiko mengalami migrain tanpa aura dikarenakan banyaknya tugas belajar. Tingkat intensitas belajar yang tinggi, kualitas tidur dan istirahat yang buruk, dan terlalu banyak menghabiskan waktu di depan komputer adalah faktor risiko lainnya. Penelitian tentang prevalensi dan penyebab migrain tanpa aura pada mahasiswa di Fakultas Kedokteran Universitas Tarumanagara diperlukan berdasarkan masalah tersebut. Metode studi analitik potong lintang digunakan untuk menyusun studi ini. Usia, jenis kelamin, tinggi badan, berat badan, kebiasaan merokok, dan kualitas tidur adalah variable-variabel yang digunakan. Hasilnya menunjukkan bahwa dari 191 mahasiswa kedokteran Universitas Tarumanagara angkatan 2021, sebanyak 67 (31,5%) mengalami migrain tanpa aura. Faktor seperti usia, jenis kelamin, kualitas tidur, obesitas dan kebiasaan merokok, tidak memiliki hubungan yang signifikan dengan migrain tanpa aura (p-value >0,05). Namun secara epidemiologi, jenis kelamin dan kualitas tidur berperan dalam kejadian migrain pada studi ini.

Purpose: WBRT and surgery are commonly used to improve the overall survival of BM patients. The study aims to evaluate the overall survival of patients treated with WBRT in combination with surgery or alone. Methods: This study is a cohort retrospective of 148 BM patients from January 1st, 2021, to December 31st, 2022, and our follow-up on their overall survival up to July 1st, 2023. We collected data on treatments received either in combination with WBRT and surgery or alone. Information for age, sex, primary tumor types, and sites of metastases were collected. Median survival time, Kaplan-Meier curves, and its’ log-rank statistics were presented, including the results of Cox regression analysis. Results: The overall median survival of this sample was 4.3 months. Patients receiving WBRT exhibit higher survival rates than non-WBRT (median survival rates are 6.9 vs 1.5 months) but not surgery (4.0 vs 4.4 months). The primary tumors (breast, lung, and others) have no difference in the median survival rates. The survival rate using Kaplan-Meier showed a significant difference between patients with WBRT vs non-WBRT (log-rank p=0.0) but not for surgery. A Cox regression shows hazard ratio (HR) for patients receiving WBRT=0.34 [95% CI: 0.19–0.62; P<0.001] and when it is adjusted for surgery and other variables it exhibits only a small change. Conclusion: BM patients who received WBRT had better survival than non-WBRT patients, which could reduce HR, but surgery was not statistically significant. All BM patients should receive WBRT regardless of surgery.