Urbanization without planning causes concerns about biodiversity loss, congestion, housing, and ecosystem sustainability in developing countries. Therefore, resilience and regeneration following urbanization are critical to city planning and sustainable development. Integrating multi-criteria decision-making methods (MCDM) with geographic information systems (GIS) can be a promising method for analyzing city resilience and regeneration. This study aims to use two MCDMs, the Analytic Network Process (ANP) and the Best–Worst Method (BWM), to evaluate the resilience of metropolitan neighborhoods in Tehran. Fourteen criteria were selected to represent the city’s resilience, and the weights of two models were evaluated for their spatial patterns using GIS. The results showed that the building age was the most important criterion in both methods, while the per capita green space was the least important criterion. The weights of the most important criterion, the building age, for the ANP and BWM, were 19.56 and 18.98, respectively, while the weights of the least important criterion, the per capita green space, were 2.197 and 1.655, respectively. Therefore, the MCDM with GIS provides an approach for assessing city resilience and regeneration priority.