This work focuses on the consensus problem for multi-agent systems (MASs) with actuator failures and time-varying state constraints, and presents a fixed-time self-triggered consensus control protocol. The use of time-varying asymmetrical barrier Lyapunov functions (BLF) avoids the violation of time-varying state constraints in MASs, ensuring stability and safety. Meanwhile, the system’s performance is further enhanced by leveraging the proposed adaptive neural networks (NNs) control method to mitigate the effects of actuator failures and nonlinear disturbances. Moreover, a self-triggered mechanism based on a fixed-time strategy is proposed to reach rapid convergence and conserve bandwidth resources in MASs. The mechanism achieves consensus within a predefined fixed time, irrespective of the system’s initial states, while conserving communication resources. Finally, the proposed method’s effectiveness is confirmed through two simulation examples, encompassing diverse actuator failure scenarios.