Aims: This study aimed to compare systemic inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), derived NLR (dNLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), in patients with vestibular neuritis (VN) and benign paroxysmal positional vertigo (BPPV) and to evaluate their potential role in differential diagnosis.Methods: In this retrospective study, 109 patients diagnosed with VN (n=52) or BPPV (n=57) at Kastamonu Training and Research Hospital were included between January 2024 and December 2024. Demographic characteristics, clinical data, and laboratory parameters (leukocyte, neutrophil, lymphocyte, monocyte, platelet, CRP, and albumin levels) were recorded. NLR, dNLR, MLR, PLR, SII [(platelet × neutrophil)/lymphocyte], and SIRI [(neutrophil × monocyte)/lymphocyte] were calculated.Results: The two groups were similar regarding age and sex distribution; however, bilateral involvement was significantly more common in the BPPV group (p=0.004). The VN group showed significantly higher leukocyte (p=0.027) and neutrophil (p=0.004) counts and significantly lower albumin levels (p=0.001). Among inflammatory markers, NLR (p=0.012), SII (p=0.023) and SIRI (p=0.035) were found to be significantly higher in VN patients than in BPPV patients.Conclusion: The significant increase in NLR, SII, and SIRI levels in VN patients compared with BPPV patients suggests a more prominent role of inflammatory mechanisms in the pathogenesis of vestibular neuritis. These readily available and inexpensive biomarkers may serve as supportive tools in the differential diagnosis of peripheral vertigo in clinical practice.

Objective: In the pathogenesis of diabetes mellitus, insufficient insulin secretion, improper glucose utilization, and insulin resistance in tissues lead to oxidative stress and inflammation and cause neuropathy in peripheral nerves. Hemoglobin, albumin, lymphocyte, and platelet (HALP) scores give an idea of nutritional and inflammatory status. In this report, we aimed to evaluate the relationship between HALP score and diabetic polyneuropathy. Materials and Methods: Patients admitted to our electrophysiology laboratory between 2022 and 2024 with a prediagnosis of polyneuropathy due to type 2 diabetes were included in the study. Demographic data (age, gender), hemogram (hemoglobin, lymphocyte, monocyte, platelet), biochemical values (fasting blood glucose, HbA1c, urea, creatinine, albumin, cholesterol, triglyceride), and electromyography results were retrospectively reviewed from the hospital information system. Results: The study included 155 type 2 diabetic patients with a prediagnosis of distal symmetric polyneuropathy; 79 had sensorimotor polyneuropathy, while 76 did not. Mean age was similar between groups, but males were more prevalent in the neuropathy group (p = 0.002). Cholesterol (p = 0.001) and platelet levels (p <0.001) were higher in the group without neuropathy, whereas HbA1c was higher in the neuropathy group (p = 0.03). No significant difference was observed in HALP scores between the two groups according to the presence of neuropathy (p = 0.327). Conclusion: The HALP score is known as a prognostic indicator, especially in patients with malignancy and ischemic stroke. This study found no statistically significant difference between the patient groups with diabetic polyneuropathy and those without diabetic polyneuropathy in terms of HALP scores. Comprehensive and more detailed studies are needed to investigate the potential of the HALP score to predict the development of diabetic neuropathy.

Background/Objectives: Neurogenic inflammation plays a key role in migraine pathophysiology. This study aimed to evaluate serum Resolvin D1 (RvD1) and Maresin 1 (MaR1) levels during acute migraine attacks and in the interictal period in the same patients, using a paired design. Methods: This prospective case–control study included 55 migraine patients and 53 healthy controls. Serum samples were obtained from each patient at two time points: during an acute attack and during the subsequent interictal period. RvD1 and MaR1 concentrations were measured using ELISA. Results: Serum RvD1 and MaR1 levels were significantly lower during migraine attacks compared with both the interictal period (p = 0.006 and p = 0.001, respectively) and healthy controls (p < 0.001). Receiver operating characteristic (ROC) analyses showed moderate discriminatory ability for RvD1 (AUC 0.719) and MaR1 (AUC 0.730). Conclusions: Reduced RvD1 and MaR1 levels are associated with the acute migraine state. These findings indicate an association rather than a causal mechanism and suggest that SPM measurements may have potential as supportive adjunct biomarkers, although further validation is required.

Aims: Thrombosis of the cerebral veins is a disease that can be caused by many factors and puts clinicians in a difficult situation during diagnosis and treatment. Our study investigated clinical findings, etiological causes, localization of thrombosis detected by neuroimaging tests, and the treatments received by the patients with cerebral venous thrombosis who were followed up as inpatients in our clinic. Methods: We retrospectively analyzed 44 patients between the ages of 18-80 years who were hospitalized with a diagnosis of cerebral venous thrombosis. Age, duration of admission, initial symptoms, neurological examination findings, Glasgow Coma Scale values at admission, etiological causes, topographic areas of involvement in neuroradiological examinations, and inpatient medical treatment were analyzed. Results: Forty-four patients (26 females, 18 males) with cerebral venous thrombosis were included in our study. According to the duration of presentation, 47.7% presented in the subacute period. Headache was the most common presenting symptom, with a rate of 90.9%, while nausea and vomiting (68.2%) and papilledema (54.5%) were the other common symptoms. Multiple vein and/or sinus involvement was present in all 17 patients with seizures. The most common etiological factors were thrombophilia (54.5%), pregnancy and the postpartum period (18.8%), and oral contraceptive use (15.9%). Multiple sinus involvement was observed in 41 patients (93.2%), while three had single sinus involvement. The rate of sinus involvement was 86.4% (38 patients) in the transverse sinus, 77.3% (34 patients) in the sigmoid sinus, and 52.3% (23 patients) in the superior sagittal sinus. Conclusion: Cerebral venous thrombosis has many etiological causes that can be overlooked due to the variety of clinical manifestations and changes in the prognosis when treated. Early treatment is essential because it can reduce the risk of death and severe disability. Our study is critical because it covers a relatively large number of cases.

Purpose: Problematic smartphone use is a prevalent behavioral issue in the digital age and is frequently associated with sleep disturbances. However, evidence on how different sleep domains respond to short-term behavioral restriction under natural conditions remains limited. This study aimed to examine smartphone use patterns in young adult males, evaluate their relationship with problematic smartphone use risk, and assess changes in sleep-related outcomes following short-term, institutionally mandated smartphone restriction. Patients and Methods: This prospective pre–post observational study was conducted at a male police college during a 10-day institution-mandated smartphone restriction. Participants (n = 254) were classified into low-risk and high-risk problematic smartphone use groups based on the Smartphone Addiction Scale–Short Version (SAS-SV). Sleep quality, sleep hygiene, insomnia severity, and daytime sleepiness were measured before and after the restriction period. Associations between smartphone use characteristics (daily duration, timing of use, and usage purposes) and sleep outcomes were examined using group comparisons and multivariate analyses. Results: At baseline, individuals classified as high-risk reported longer overall smartphone use, particularly during evening hours, together with poorer sleep hygiene, lower perceived sleep quality, and greater daytime sleepiness. After the restriction period, improvements were mainly observed in behaviorally related sleep measures, including sleep hygiene and subjective sleep quality. In contrast, insomnia severity and daytime sleepiness showed limited change and did not demonstrate a significant group-by-time interaction. Conclusion: The findings suggest that intensive evening smartphone use may be associated with sleep difficulties that are largely behaviorally mediated. Improvements in sleep-related behaviors accompanied short-term reductions in device exposure, whereas sleep parameters linked to more stable physiological regulation appeared less responsive over this brief interval. Addressing the timing and intensity of smartphone use is a relevant behavioral target in strategies to improve sleep health in young adults.

Aims: Restless legs syndrome (RLS) has been linked to systemic inflammation. The number of studies investigating inflammation in RLS patients is extremely limited. The purpose of this study is to examine the possible role of proinflammatory parameters in RLS, specifically neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and microR. Methods: The study included 100 patients admitted to the neurology outpatient clinic diagnosed with RLS using the International Restless Legs Syndrome Study Group ((IRLSSG) scale and 100 healthy controls. Hemogram results were obtained from both RLS patients and healthy controls, while ferritin, folate, vitamin D and B12, and C-reactive protein (CRP) levels were obtained only from RLS patients. Results: The median age of the patient group was 52.50 (43-60.75), while the median age of the healthy group was 51.00 (50-53). The patient group is 37% male, while the healthy group is 34% male. It doesn't vary by age or gender (p=0.658). The two groups showed significant differences in PLR (