Alex S. Siebner is a German scientist whose work includes neglected tropical diseases (Schistosomiasis) and systems neurodegenerative diseases (protein intrinsic disorder). He is affiliated with the Institute for Tropical Medicine at the University of Tübingen and the German Center for Infection Research (DZIF), where he is interested in IgG subclass switch after mRNA-COVID-19 vaccination and Schistosomiasis, linking these mechanistically. His recent work has explored immunological responses to vaccination and infection, including studies on IgG4 class switching witch is more pronounced in BNT162b2 compared to mRNA-1273 and its potential implications for immune tolerance. Within the same context, Siebner has contributed to interdisciplinary research examining how helminth infections and immune regulation influence vaccine efficacy and host–pathogen interactions in endemic settings with a systematic literature review. In parallel, his research engages with emerging concepts in neurodegenerative disease, particularly the role of intrinsically disordered proteins (IDPs) in protein aggregation, phase separation, and neurotoxicity. By linking immune mechanisms with protein homeostasis and neuronal vulnerability, his work contributes to a broader understanding of how systemic factors may intersect with molecular pathways in disorders such as Alzheimer’s disease and amyotrophic lateral sclerosis.