The impact of climate change on hydrology and water salinity of a valuable coastal wetland (Anzali) in northern Iran is assessed using daily precipitation and temperature data from 19 models of Coupled Model Inter-comparison Project Phase 5. The daily data are transiently downscaled using the Long Ashton Research Station Weather Generator to three climatic stations. The temperature is projected to increase by +1.6, +1.9 and +2.7°C and precipitation to decrease by 10.4%, 12.8% and 12.2% under representative concentration pathway (RCP) scenarios RCP2.6, RCP4.5 and RCP8.5, respectively. The wetland hydrology and water salinity are assessed using the water balance approach and mixing equation, respectively. The upstream river flow modelled by the Soil and Water Assessment Tool is projected to reduce by up to 18%, leading to reductions in wetland volume (154 × 10⁶ m³), area (57.47 km²) and depth (2.77 m) by 34%, 21.1% and 20.2%, respectively, under climate change, while the mean annual total dissolved solids (1675 mg/L) would increase by 49%. The reduced volume and raised salinity may affect the wetland ecology.