This study examines the analysis of entropy generation in the magnetohydrodynamic oscillatory convective flow of hybrid nanofluid through a porous horizontal channel with velocity slip. The analysis incorporates suction at the cold wall and injection at the hot wall. Variable viscosity, thermal radiation, and viscous dissipation are also considered. Utilizing similarity transformations, the governing nonlinear partial differential equations are converted into ordinary differential equations, and exact solutions are obtained using Mathematica. Graphs are used to illustrate the impact that a variety of physical factors have on velocity, temperature, entropy generation, the Bejan number, skin friction, and the Nusselt number. The graphic results demonstrate that the fluid velocity is positively correlated with the cold wall slip parameter and negatively correlated with the hot wall slip parameter. There is an opposite relationship between fluid temperature and thermal radiation and an ascending relationship between fluid temperature and the Brinkman number. Findings from this study have important implications for better thermal management, device performance, and reliability as well as for optimizing microelectronic cooling systems.