Both the second-reading mode and concurrent-reading mode have the potential to improve novice readers’ performance for breast cancer screening on an automated breast US. BackgroundComputer-aided detection (CAD) systems may be used to help radiologists interpret automated breast (AB) US images. However, the optimal use of CAD with AB US has, to the knowledge of the ...

Coal is one of the main sources of human energy. In the process of coal mining, separating gangue from coal has great significance for environmental protection and energy conservation. The core problem in the separation of gangue is the recognition of coal and gangue. In this study, multispectral technology was used to identify gangue. First, set up a data acquisition system in the laboratory, and then collect spectral data. Coal and gangue spectral data were collected in 202 and 201 groups, respectively. Secondly, design a spectral data dimension reduction model called two-dimension autoencoder(2D-AE). Finally, Random Forest was used to recognize coal and gangue. Meanwhile, CART, KNN, SVM, and AdaBoost were also used for gangue identification. The experimental results show that the maximum average accuracy by 2D-AE combined with RF was the largest, which was 98.89%. Also, the accuracy of gangue recognition is different for spectral images of different wavelengths. This paper mainly studies the recognition of coal and gangue based on multispectral technology, which is of great significance for the next step of detecting gangue based on the technology.

Objectives: To noninvasively estimate three breast cancer biomarkers, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) and enhance performance and interpretability via multi-task deep learning. Methods: The study included 388 breast cancer patients who received the 3D whole breast ultrasound system (3DWBUS) examinations at Xijing Hospital between October 2020 and September 2021. Two predictive models, a single-task and a multi-task, were developed; the former predicts biomarker expression, while the latter combines tumor segmentation with biomarker prediction to enhance interpretability. Performance evaluation included individual and overall prediction metrics, and Delong’s test was used for performance comparison. The models’ attention regions were visualized using Grad-CAM + + technology. Results: All patients were randomly split into a training set (n = 240, 62%), a validation set (n = 60, 15%), and a test set (n = 88, 23%). In the individual evaluation of ER, PR, and HER2 expression prediction, the single-task and multi-task models achieved respective AUCs of 0.809 and 0.735 for ER, 0.688 and 0.767 for PR, and 0.626 and 0.697 for HER2, as observed in the test set. In the overall evaluation, the multi-task model demonstrated superior performance in the test set, achieving a higher macro AUC of 0.733, in contrast to 0.708 for the single-task model. The Grad-CAM + + method revealed that the multi-task model exhibited a stronger focus on diseased tissue areas, improving the interpretability of how the model worked. Conclusion: Both models demonstrated impressive performance, with the multi-task model excelling in accuracy and offering improved interpretability on noninvasive 3DWBUS images using Grad-CAM + + technology. Critical relevance statement: The multi-task deep learning model exhibits effective prediction for breast cancer biomarkers, offering direct biomarker identification and improved clinical interpretability, potentially boosting the efficiency of targeted drug screening. Key Points: Tumoral biomarkers are paramount for determining breast cancer treatment. The multi-task model can improve prediction performance, and improve interpretability in clinical practice. The 3D whole breast ultrasound system-based deep learning models excelled in predicting breast cancer biomarkers. Graphical

Dang X, et al. J Breast Cancer. 2022 Jul;25:e32. https://doi.org/10.4048/jbc.2022.25.e32

Computational histopathology is a fast emerging field which converts the traditional glass slide based department to a new examination platform. Such a paradigm shift also brings the in silico computation to the field. Much research have been presented in the past decades on the algorithm development for pathology image analysis. On the other hand, a comprehensive software platform with advanced visualization and computation capability, large developer community, flexible plugin mechanism, and friendly transnational license, would be extremely beneficial for the entire community. In this work, we present SlicerScope: an open platform for whole slide histopathology image computing based on the highly successful 3D Slicer. We present rationale on the choice of such an architecture, introducing new modules/tools for giga-pixel whole slide image viewing, and four specific analytical modules for qualitative presentation, nucleus level analysis, tissue scale computation, and 3D pathology. The entire software is publicly available at https://slicerscope.github.io/, facilitating the algorithmic, clinical, and transnational researches.