Despite extensive research on climate change impacts and adaptation strategies in Zimbabwe, their effectiveness from the perspective of smallholder farmers, particularly in the Gwayi catchment remains insufficiently understood. This study evaluated adaptation strategies in response to land use change and climate variability using a mixed-methods approach. Data were collected through a survey of 483 smallholder farmers, 10 focus group discussions (8–12 participants), and interviews with 25 key informants. Results show that despite farmers' awareness of improved practices, adaptation remains constrained by limited access to water, quality seeds, and technology (64%), financial constraints (46%), and knowledge gaps (19%). The most common adaptation strategies include soil water conservation (85%), drought-resistant crops (80%), early planting (55%), and diversification (49%), with soil water conservation and drought-tolerant crops being the most widely practiced and perceived as most effective. Regression analysis indicates that livestock ownership, participation in community climate-resilient programs, and recent drought experiences significantly (p < 0.05) influence both the choice and number of adaptation strategies adopted. These findings highlight the need for context-specific interventions to mitigate the impacts of climate and land use changes on food security. Strengthening resilience among smallholder farmers requires improved resource access, livestock support, community-based resilience programs, capacity building, financial aid, and enhanced drought preparedness. Implementing these measures will bolster adaptive capacity and promote sustainable agricultural practices in the face of climate uncertainty.