Resumo Fundamento A contagem corrigida de quadros TIMI (CTFC), o grau de blush miocárdico (MBG) e a resolução do segmento ST (STR) são parâmetros utilizados para avaliar a reperfusão em nível microvascular em pacientes submetidos à intervenção coronária percutânea primária (ICPp). A relação fibrinogênio/albumina (FAR) tem sido associada a eventos trombóticos em pacientes com infarto do miocárdio com elevação do segmento ST (IAMCSST) e insuficiência venosa crônica. Objetivos Investigar a relação do FAR com CTFC, MBG e STR.Métodos: O estudo [...] Resumo Fundamento A contagem corrigida de quadros TIMI (CTFC), o grau de blush miocárdico (MBG) e a resolução do segmento ST (STR) são parâmetros utilizados para avaliar a reperfusão em nível microvascular em pacientes submetidos à intervenção coronária percutânea primária (ICPp). A relação fibrinogênio/albumina (FAR) tem sido associada a eventos trombóticos em pacientes com infarto do miocárdio com elevação do segmento ST (IAMCSST) e insuficiência venosa crônica. Objetivos Investigar a relação do FAR com CTFC, MBG e STR.Métodos: O estudo

Background: Transcatheter aortic valve replacement (TAVR) is widely used in patients with severe aortic stenosis. The HALP (hemoglobin, albumin, lymphocyte, and platelet) score is an easily obtainable composite index that reflects nutritional status and systemic inflammation. Methods: In this single-center retrospective study, 140 patients who underwent TAVR between 1 April 2021, and 31 October 2024, were included. Patients were stratified according to the median HALP score (32.65) into low (5 units of red blood cells, acute kidney injury (AKI), need for mechanical ventilation >24 h, and length of hospital stay. Associations between the HALP score and clinical outcomes were evaluated using multivariable regression analyses, and the discriminatory performance of HALP was assessed using receiver operating characteristic (ROC) curves. Results: Patients with low HALP scores had higher rates of in-hospital mortality (11.4% vs. 4.2%; p = 0.002), bleeding (28.6% vs. 5.7%; p < 0.001), AKI (11.4% vs. 2.9%; p < 0.001), and need for mechanical ventilation >24 h (25.7% vs. 14.4%; p = 0.002), as well as longer hospital stay (4.82 ± 1.50 vs. 3.62 ± 1.94 days; p = 0.001) compared with the high-HALP group. In multivariable models, a lower HALP score remained independently associated with all adverse in-hospital outcomes. ROC analysis showed good discriminatory ability of the HALP score for mortality (area under the curve [AUC] = 0.816; cut-off = 20.16), bleeding (AUC = 0.798; cut-off = 24.94), AKI (AUC = 0.737; cut-off = 26.21), and need for mechanical ventilation (AUC = 0.735; cut-off = 27.36). Conclusions: The HALP score is independently associated with adverse in-hospital clinical outcomes in patients undergoing TAVR and may serve as a simple and practical tool for early risk stratification in this population.

Amaç: Koroner arter hastalığı (KAH), hem gelişmiş hem de gelişmekte olan ülkelerde önde gelen ölüm nedenidir. Ateroskleroz kronik bir inflamatuvar süreçtir. Hemoglobin, albümin, lenfosit ve trombosit düzeylerinin ölçümlerini içeren HALP skoru, son zamanlarda hem sistemik inflamasyonu hem de beslenme durumunu değerlendirmek için pratik ve kullanımı kolay bir araç olarak kabul edilmiştir. Bu çalışmada, HALP skorunun KAH’ın şiddetini öngörmedeki değerini araştırmayı amaçladık. Materyal ve metod: Çalışmaya, Haziran 2023 ile Şubat 2025 arasında kliniğimizde şüpheli KAH nedeniyle koroner anjiyografi (KAG) uygulanan 450 ardışık hasta, retrospektif olarak dahil edildi. Hastalar, KAH ciddiyetinin derecelendirilmesi için Gensini skorlaması kullanılarak normal, hafif ve şiddetli koroner ateroskleroz olarak kategorize edildi. HALP skoru, KAG'den önce elde edilen tam kan sayımı ve biyokimyasal verilerden hesaplandı. Bulgular: Hastalar, medyan HALP kesme değeri olan 52.05'e göre iki gruba ayrıldı. Kesme değeri 52.05'ten büyük olan hastalar yüksek HALP skoru, kesme değeri 52.05'ten küçük olan hastalar ise düşük HALP skoru olarak tanımlandı. HALP skoru düşük olan grupta HALP skoru yüksek olan gruba göre Gensini skoru anlamlı olarak daha yüksek idi (p=0.02). Ek olarak, Gensini skoruna göre KAH ciddiyeti arrtıkça HALP skorunun da anlamlı olarak azaldığı tespit edildi (p=0.01). Yapılan korelasyon analizinde HALP skorunun Gensini skoru ile negatif bir şekilde korele olduğu tespit edildi (r= -0.526, p< 0.001). Yapılan regresyon analizinde HALP skoru, Gensini skorunun bağımsız bir öngördürücüsü olarak tespit edildi (β = –0.37, p < 0.001). Sonuç: Bu çalışma, HALP skorunun KAH’ın şiddetini öngörmede yararlı bir gösterge olabileceğini göstermiştir

Resumo Fundamento: Sabe-se que a rigidez aórtica (RA) aumenta em pacientes com disfunção erétil (DE). Os inibidores da enzima fosfodiesterase tipo 5 (PDE-5) são usados no tratamento da DE, e as respostas dos pacientes a esse tratamento podem variar. Objetivos: Nosso objetivo foi investigar o papel da RA na previsão da resposta de pacientes planejados para tomar inibidores da enzima PDE-5 devido à DE. Métodos: Um total de 96 pacientes do sexo masculino com DE foram incluídos no estudo. O [...] Resumo Fundamento: Sabe-se que a rigidez aórtica (RA) aumenta em pacientes com disfunção erétil (DE). Os inibidores da enzima fosfodiesterase tipo 5 (PDE-5) são usados no tratamento da DE, e as respostas dos pacientes a esse tratamento podem variar. Objetivos: Nosso objetivo foi investigar o papel da RA na previsão da resposta de pacientes planejados para tomar inibidores da enzima PDE-5 devido à DE. Métodos: Um total de 96 pacientes do sexo masculino com DE foram incluídos no estudo. O

SUMMARY OBJECTIVE: Remnant cholesterol is an important component of triglyceride-rich lipoproteins and has emerged as an important potential biomarker for the assessment of cardiovascular risk. The aim of the study is to examine acute changes in remnant cholesterol levels pre- and post-angiography and evaluate their relationship with inflammatory markers. METHODS: A total of 183 patients who underwent coronary angiography were included in this retrospective study. Remnant cholesterol, low-density lipoprotein, high-density lipoprotein, creatine kinase-myocardial band, Troponin-T, C-reactive protein, and white blood cell levels were analyzed pre- and post-angiography. Correlation and regression analyses were used to evaluate the relationships between the data. RESULTS: Remnant cholesterol levels increased significantly post-angiography (p<0.05), while low-density lipoprotein showed no significant change (p=0.0588). C-reactive protein levels were significantly higher post-angiography than pre-angiography (p<0.05), which was considered as an indicator of procedure-related inflammatory response. Correlation analysis found a significant inverse relationship between baseline remnant cholesterol and post-angiography C-reactive protein (p0.05). Baseline remnant cholesterol (pre-angiography) levels showed an inverse association with post-procedure troponin T (β=-0.014, p0.05). CONCLUSION: This study reveals significant post-angiography increases in remnant cholesterol, indicating acute metabolic and inflammatory changes. While these findings enhance understanding of remnant cholesterol dynamics during vascular interventions, the lack of long-term outcomes necessitates cautious interpretation. Future research should validate its prognostic value and therapeutic implications. Remnant cholesterol shows potential as a biomarker but requires further investigation before clinical implementation.

Background/Objectives: Pregnancy is associated with profound physiological alterations that, together with anemia and spinal anesthesia, may influence myocardial repolarization. The frontal QRS-T [f(QRS-T)] angle has emerged as a reliable electrocardiographic parameter for evaluating repolarization heterogeneity. Materials and Methods: This observational prospective study included 100 term pregnant women [18–45 years, American Society of Anaesthesiologists (ASA) II] undergoing elective cesarean delivery under spinal anesthesia at Sanliurfa Training and Research Hospital between May and August 2025. Participants were divided into two groups: anemic (Hb < 10.5 g/dL, n = 50) and non-anemic (Hb ≥ 10.5 g/dL, n = 50). Standard monitoring and 12-lead ECGs were performed preoperatively and postoperatively. The f(QRS-T) angle was calculated as the absolute difference between QRS and T axes; values > 180° were adjusted by subtracting from 360°. Results: Demographic variables were comparable between groups. No significant differences were observed in mean arterial pressure or heart rate. Preoperative QTc and f(QRS-T) angle values did not differ significantly. However, postoperative QTc was prolonged in the anemic group compared with non-anemic women (426.3 ± 19.2 ms vs. 417.2 ± 20.7 ms, p = 0.026). Likewise, the postoperative f(QRS-T) angle was significantly higher in anemic patients (29.5 [16.0–45.3] vs. 20.5 [9.8–34.5], p = 0.017). Within-group analysis revealed significant postoperative increases in both QTc (p < 0.001) and f(QRS-T) angle (p < 0.001) in the anemic group, but not in controls. Hemoglobin levels correlated negatively with postoperative QTc (r = −0.267, p = 0.008) and f(QRS-T) angle (r = −0.264, p = 0.008). Conclusions: In anemic patients undergoing cesarean delivery under spinal anesthesia, the postoperative QTc interval and f(QRS-T) angle increased significantly compared with both baseline values and non-anemic counterparts. Assessment of the f(QRS-T) angle, a simple and inexpensive ECG-derived parameter, may aid in perioperative risk stratification and enhance patient safety.