Mechanical stimuli have multiple effects on cell behavior, affecting a number of cellular processes including orientation, proliferation or apoptosis, migration and invasion, the production of extracellular matrix proteins, the activation and translocation of transcription factors, the expression of different genes such as those involved in inflammation and the reprogramming of cell fate. The recent development of cell stretching devices has paved the way for the study of cell reactions to stretching stimuli in-vitro, reproducing physiological situations that are experienced by cells in many tissues and related to functions such as breathing, heart beating and digestion. In this work, we review the highly-relevant contributions cell stretching devices can provide in the field of mechanobiology. We then provide the details for the in-house construction and operation of these devices, starting from the systems that we already developed and tested. We also review some examples where cell stretchers can supply meaningful insights into mechanobiology topics and we introduce new results from our exploitation of these devices.
As global food demand rises and agricultural labor shortages intensify, robotic automation has become essential for sustainable fruit grasping. Among emerging technologies, ElectroAdhesion (EA) grippers offer a promising alternative to traditional mechanical end-effectors, enabling gentle, low-pressure handling through electrostatically induced adhesion. This paper presents a methodical review of EA grippers applied to fruit grasping, focusing on their advantages, limitations, and key design considerations. A targeted literature search identified ten EA-based and hybrid EA gripping systems tested on fruit manipulation, though none has yet been tested in real-world environments such as fields or greenhouses. Despite a significant variability in experimental setups, materials, and grasp types, qualitative insights are drawn from our analysis demonstrating the potentialities of EA technologies. The EA grippers found in the targeted review are effective on diverse fruits, shapes, and surface textures; they can hold load capacities ranging from 10 g (~0.1 N) to 600 g (~6 N) and provide minimal compressive stress at high electrostatic shear forces. Along with custom EA grippers designed accordingly to specific use cases, field and greenhouse testing will be crucial for advancing the technology readiness level of EA grippers and unlocking their full potential in automated crop harvesting.