BACKGROUND: It is known that there is a relationship between hearing loss, which is an important cause of disability, psychological symptoms, and low quality of life. The aim of this study is to evaluate the anxiety, depression levels, and quality of life analysis of adults with postlingual hearing loss and who have undergone cochlear implants and to compare them with the data of subjects who have never had a hearing loss. METHODS: The prospective controlled clinical study included 53 subjects who had cochlear implants and 52 healthy controls in terms of hearing. Hospital Anxiety and Depression Scale and Short Form 36 were filled by all subjects to investigate their depression, anxiety, and quality of life levels. RESULTS: The mean age of subjects was 42.88 ± 18.04, and 44% (23) were women. There was no significant difference between the study and control groups in terms of Hospital Anxiety and Depression Scale scores. Short Form 36 physical role (P = .018) and SF-36 general health (P = .014) in quality of life assessment sub-scores were statistically significantly higher in the study group than in the control group. When the correlation between the time elapsed after surgery and Hospital Anxiety and Depression Scale scores and Short Form 36 scores was evaluated, no significance was observed. CONCLUSION: The fact that the patients evaluated after cochlear implant surgery had similar depression and anxiety levels and quality of life as the controls, and even physical role and being significantly better in general health compared to the controls reveal the importance of regaining the hearing ability. Cite this article as: Yeni Elbay R, Bakıcı B, Kalcıoglu MT. Depression, anxiety, and quality of life in patients with cochlear implant: A case-control study. J Int Adv Otol. 2023;19(2):81-86.

To evaluate the potential ototoxic effects of lactoferrin on the inner ear using electrophysiological and histological methods. Methods: Thirty-two Sprague-Dawley rats (64 ears) were divided into four groups: control, saline, antiseptic solution (70% isopropyl alcohol + 2% chlorhexidine), and lactoferrin. Groups II–IV received three intratympanic injections. Auditory brainstem response (ABR) tests were performed at baseline, day 7, and day 21. Cochlear histology and VEGF immunoreactivity were assessed. Results: Baseline hearing was similar across groups. Post-treatment, Groups II and IV showed partial recovery at 8, 16, and 24 kHz, while Groups III and IV had worsening thresholds at higher frequencies. Histologically, Group IV’s cochlear structures remained largely intact. VEGF immunoreactivity was severe to moderate in Groups I, II, and IV, and weaker in Group III. Conclusions: Lactoferrin showed relative safety at lower frequencies but possible ototoxicity at higher frequencies. However, no significant structural damage was observed in cochlear tissues.

Background: Endoscopes play an important role in otologic surgery. Baby shampoos, known for their hypoallergenic, anti-irritant, and antifogging properties, are increasingly being used. The purpose of this study was to evaluate the safety and ototoxic effects of baby shampoo in ananimal model using both electrophysiological and histological methods. Methods: Twenty-eight male Sprague–Dawley rats were divided into 4 groups: 7 control (group 1), 7 saline (group 2), 7 isopropyl alcohol(70%)+chlorhexidine (2%) antiseptic (group 3), and 7 baby shampoo (group 4). Baseline hearing was assessed by auditory brainstem response(ABR). All groups except the control received 3 doses of their respective substances by intratympanic injection. Auditory brainstem responsemeasurements were performed on day 7 and day 21, after which the temporal bones were dissected. Histological evaluation of the cochlea andvascular endothelial growth factor (VEGF) immunoreactivity studies were performed. Results: Baseline hearing thresholds were similar and within normal limits. On days 7 and 21, hearing thresholds were significantly impairedat all frequencies in the experimental groups. In particular, groups 3 and 4 had higher thresholds than the other groups. Baby shampoo causedsignificant damage to outer hair cells and sustentacular cells and decreased VEGF immunoreactivity in the stria vascularis, spiral ligament, andorgan of Corti.Conclusion: Baby shampoo was found to progressively impair hearing over time, indicating its potential to cause long-term ototoxicity.Cite this article as: Mutlu A, Bakici B, Yasemin Gunduz A, et al. Progressive ototoxicity of baby shampoo as an antifog agent: an experimentalstudy. J Int Adv Otol. 2025, 21(2), 1526, doi: 10.5152/iao.2025.241526.