Objective: Glycemic variability (GV) is a new term with the episodes of hyper and hypoglycemia in diabetic patients. Both prolonged QT interval and QTd are potential risk factors for malignant ventricular arrhythmias affecting the mortality of different groups of patients including diabetes mellitus. In this study, we aimed to evaluate if the glucose variability increasing the QTc interval and QTc dispersion in type 2 diabetes mellitus.Methods: We included 275 consecutive patients with type 2 diabetes. We quantified the GV with standard deviation (SD) and coefficient of variation (CV) from 7 point glucose measures. We investigated the relationship of GV parameters with QT parameters.Results: The prevalence of prolonged QTc duration was 21%, no patients have prolonged QTc dispersion (> 80 ms). SD of the patients with prolonged QTc duration was significantly higher than the others (45.14

Giriş ve Amaç: Çalışmanın amacı sunulan evde sağlık hizmetlerini ve hastaların sağlık durumlarını değerlendirmektir. Gereç ve Yöntem: İstanbul İl Sağlık Müdürlüğü Kamu Hastaneleri Hizmetleri Başkanlığı-2’ye bağlı Üsküdar Evde Sağlık Hizmetleri Koordinasyon Merkezi’nden hizmet almış hastalar arasından Basit Tesadüfi Örnekleme Yöntemi ile seçilen 525 hasta çalışmaya dahil edilmiştir. Veriler fiziki ve elektronik hasta dosyalarından elde edilmiştir. Çalışma tanımlayıcı ve kesitsel olarak planlanmış ve elde edilen veriler sayı ve oran (%) olarak gösterilmiştir. Bulgular: Hastaların bağımlılık durumu yüksektir. Hastaların %8’i oral beslenememekte ve %32’si destekleyici beslenme ürünü almaktadır. %11’inde mesane katateri, %2’sinde trakeostomi kanülü bulunmaktadır. %7’si mevsimsel grip aşısı ve yalnızca 2 kişi pnömokok aşısı yaptırmıştır. Son bir yıl içinde hastaların %12’si konstipasyon sorunu yaşamış, %10’u en az bir kere üriner sistem enfeksiyonu geçirmiş ve %12’sinde dekübit ülseri meydana gelmiştir. %43’üne duygu durum bozukluğu (anksiyete/depresyon) tanısı konmuş ve bununla ilgili ilaç tedavisi başlanmıştır. Hastalara en sık konulan tanılar sırasıyla hipertansiyon, Alzheimer/demans, kalp hastalıkları, diyabet ve serebrovasküler hastalıklardır. Sonuç: Hastaların sağlık ihtiyaçlarının yüksek olduğu bulunmuştur.

Introduction : Diabetes mellitus (DM) is a metabolic disorder associated with both microvascular and macrovascular complications. Mean platelet volume (MPV) is a marker of platelet activity, which plays a major role in the development of vascular complications of DM. The aim of this study is to...

Objectives: We aimed to evaluate the effects of acute and chronic aerobic exercise on cognitive function and depression levels in patients with Type 2 Diabetes Mellitus (T2DM) and the changes in related neurotrophic and metabotropic factors. Methods: Sixteen female patients (age=57.5 ± 7.3) diagnosed with T2DM were included. A and B sections of the Trail Making Test (TMT) and Beck Depression Inventory (BDI) were used to assess executive function and depression states. Brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), irisin, total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), fasting plasma glucose, hemoglobin A1c, and high-density lipoprotein (HDL) cholesterol were analyzed in blood. Aerobic exercise intensity was applied at 50–70% of the maximal heart rate for 40 min/day, three days weekly on the treadmill. All evaluations were repeated after one exercise session, a 12-week exercise program, and after one year for follow-up. Results: TMT-A (p=0.001) and TMT-B (p=0.002) values were increased following both acute and chronic exercise. BDI scores were decreased after long-term exercise (p=0.031). Measurement of metabolic parameters revealed positive changes in HDL cholesterol (p=0.044), TAS (p=0.005), and OSI (p=0.009) values ​​after chronic period exercise. No significant difference was found in BDNF (p=0.271), NGF (p=0.230), and irisin (p=0.101) values ​​after acute or chronic exercise, on the other hand. Conclusions: Although aerobic exercise training had a positive effect on metabolic and cognitive outcomes, this effect was independent of neurotrophic and metabotropic factors. Regular and long-term aerobic exercise training has protective and regulatory functions in T2DM.

OBJECTIVE: We aimed to compare the effects of blood groups and Rh factor on the development of coronavirus-19 disease (COVID-19) with all aspects such as clinical course, inflammatory parameters, and organ-specific biochemical parameters with a significant number of patients. METHODS: This multicenter study was carried out retrospectively on 3551 patients hospitalized with the diagnosis of COVID-19 and whose blood groups were recorded during the time of hospitalization. As control groups, 22133 individuals' medical data who were admitted to the blood bank affiliated with our hospitals during the last year was used. The differences between the blood groups and clinical characteristics were analyzed. RESULTS: Of the 3551 patients, A Rh (+) blood group was found to be in a higher ratio in the case group than controls, with increased risk to be infected (case: 41.3% vs. control: 38.8%), (OR 1.113; 95% CI: 1.036-1.197; p=0.003). Meanwhile O Rh (+) blood group ratios were significantly lower in the case group than in the control group (case: 26% vs. control: 28.3%) (OR 0.862; 95% CI: 0.823-0.966; p=0.005). There was no significant difference between blood groups in terms of admission to the intensive care units and mortality, it was observed that patients with AB Rh (+) blood group have a greater risk for intubation than others (OR: 1.467; 95% CI: 1.040-2.071; p=0.028). CONCLUSION: We demonstrated that people with blood group A Rh (+) more susceptible to COVID-19, whereas blood group 0 Rh (+) have a protective effect against the infection. Once a person has been infected with severe acute respiratory syndrome coronavirus 2, we should be mindful that patients with blood group AB Rh (+) would be prone to intubation more than other blood groups.