This article deeply analyzes the current situation and key technologies of cotton production in Xinjiang. From 2020 to 2024, the average total fiber yield, planting area, and unit yield of cotton in Xinjiang reached 5.296 million tons, 2.4644 million hectares, and 2149.72 kg/ha, respectively. Among them, the highest total yield, planting area, and unit yield were 5.686 million tons, 2.5061 million hectares, and 2322.8 kg/ha, respectively. Additionally, the cotton quality of Xinjiang is excellent, and the comprehensive mechanization operation coverage rate has reached 97.0%. The success of Xinjiang’s cotton industry is primarily attributed to the development and promotion of a series of cotton planting technologies with distinct regional characteristics and leading technological levels, including identifying the “early, short, and dense” cultivation mode as a technological breakthrough, integrating comprehensive prevention and control of pest, disease, weed, and natural disaster, water-saving through mulched drip irrigation, and standardized management of mechanically harvested cotton. These technologies fully demonstrate the high adaptability of local cotton production techniques to natural conditions. Through these advanced technologies, the unfavorable factors of relatively poor natural ecological conditions in Xinjiang’s cotton region have been overcome, and the goal of high and stable cotton yield, high quality, simple, and efficient, has been successfully achieved. Xinjiang cotton not only provides strong support for local economic and social development, but also offers a “China Xinjiang cotton cultivation application plan” for the high quality and sustainable development of global cotton, particularly in cotton production areas with similar natural ecological conditions as Xinjiang.