Genitourinary syndrome of menopause (GSM), which includes vulvovaginal atrophy (VVA) and other bothersome genitourinary symptoms, affects over half of postmenopausal women and has a considerable impact on quality of life. This study aimed to evaluate the efficacy and safety of an injectable combination of hyaluronic acid and amino acids for treating GSM-related symptoms. In this prospective, multicenter study, 84 women aged 46–60 with moderate to severe VVA confirmed by gynecological examination received three intradermal treatments at 21-day intervals, targeting the vestibule, introitus, lower vaginal wall, and labia majora. Symptom severity was assessed using a visual analog scale (VAS), while tolerability and satisfaction were evaluated via a five-point Likert scale. Quality of life was measured using the Satisfaction With Life Scale (SWLS). Assessments were conducted at baseline, after each injection, and at 3- and 6-month follow-up visits. After three months, significant improvements were noted in vaginal dryness, itching, burning, and dyspareunia (all p < 0.001). Patient satisfaction increased from 59.0% to 80.7%, and SWLS scores rose from 4.57 ± 1.76 to 6.53 ± 1.10, reflecting enhanced quality of life. The treatment was well tolerated and demonstrated a favorable safety profile. These findings suggest that this injectable formulation may represent an effective, non-hormonal option for women with VVA, particularly those who are not candidates for hormone therapy.

Introduction: Skin aging is a complex biological phenomenon, it is the result of an intrinsic decline in cellular functions due to age and genetically programmed, added to a continuous exposure of various harmful external factors that influence its trend. Both mechanisms modify the structure of the extracellular matrix (ECM) by acting on the quantity and composition of its proteins: type III collagen constitutes 50% of the collagen in the dermis of the neonatal skin but only 5% of the collagen in the aging adult skin, type IV collagen, an important component of the basement membrane, forms anchor plates between types of structural collagen, it decreases with age after 35 years affecting the thickness of the epithelial basement membrane significantly. Aims of the study: The Aim of the study was to evaluate the therapeutic effects of a new pre-mixed injectable product of not cross-linked LMW Hyaluronic Acid (50-250 KDaltons) added to a specific mixture of six amino acids ( HY6AA + Formula) to improve the signs of chrono and photo-aging of the skin of the facial area, through a simple and minimally invasive injectable procedure with fast obtaining results. Materials and methods: The open clinical pilot trial was conducted by two centres under medical control. 3,5 ml HY6AA+Formula was performed by injecting 3 times at intervals of 2 weeks each. The Visia device as well as the GAIS (Global Aesthetic Improvement Scale) and VAS scale, the skin elasticity scale and the wrinkle correction scale were used for the assessment. Efficacy evaluations were performed previously to each injection treatment, performed every two week for three times, and 4 weeks after the third injection. Skin elasticity was evaluated by Pinching Test immediately after each treatment and at 4 weeks after the third injection. Conclusions: The photo analysis by Visia device proves the significant effectiveness of HY6AA + Formula. The data recorded on the skin texture improvement, dyschromia and skin elasticity are very encouraging, especially considering the minimal invasiveness of the procedure and the limited number of sessions required. The improvement of skin quality in most cases occur after the first treatment, and as the treatment protocol progresses, patients' feelings and their individual assessment of skin quality also gradually improve.

Background: Labia majora atrophy is a common consequence of aging, hormonal changes, and medical conditions, leading to anatomical changes that affect both aesthetic appearance and sexual function. Hyaluronic acid (HA)-based fillers represent a promising, minimally invasive approach to restoring volume and improving the structural integrity of the labia majora. However, clinical data on their efficacy and safety remain limited. Objective: To evaluate the efficacy and safety of a cross-linked hyaluronic acid filler for the treatment of labia majora hypotrophy. Methods: This randomised, single-centre, double-arm study included 76 women aged 40–65 years with labia majora hypotrophy, allocated to either a treatment group receiving HA filler injections (n = 40) or a control group with no intervention (n = 36). Primary endpoints included changes in sexual function, assessed using the Female Sexual Function Index (FSFI) at six months, and anatomical assessment using the Motakef classification as an indirect measure of the labia majora proportion. Secondary endpoints included aesthetic improvement (Global Aesthetic Improvement Scale, GAIS), perceived stress (Perceived Stress Scale, PSS), and patient satisfaction. Safety was assessed through the systematic monitoring of adverse events. Results: At six months, FSFI scores significantly improved in the treatment group compared to the control group (p < 0.0001), indicating improved sexual function. GAIS scores demonstrated significantly higher aesthetic improvement in the treated group (p < 0.0001). No serious adverse events occurred, and procedure-related pain was minimal (mean NRS: 1.4 ± 1.2). The treatment was well tolerated, with only transient and mild local reactions reported. Conclusions: The findings suggest that HA-based gynaecological fillers may represent a safe and potentially effective minimally invasive option for labia majora augmentation, with improvements in sexual function, aesthetic appearance, and patient satisfaction. These results should be considered preliminary and warrant further long-term investigation.

Non-invasive subcutaneous hyperthermic laser lipolysis could be an alternative to classic surgical liposuction. In this study the same physician treated 32 patients (22 females and 10 males) mainly in the abdomen and in the trochanteric region for 2 sessions, with specific and well-described settings. This treatment resulted to be extremely successful based on body weight, abdomen circumference, trochanteric circumference, abdomen subcutaneous fat ultrasound, trochanteric subcutaneous fat ultrasound. No adverse events were reported. Non-invasive subcutaneous hyperthermic laser lipolysis represents, therefore, a potential alternative to classic surgery in selected cases.