Regenerating dentin-pulp complex (DPC) using tissue engineering offers a novel and promising therapeutic alternative for restoring teeth. A crucial component of such a therapy is the designing and fabrication of an appropriate 3D Scaffold. In this review, we set out to highlight some of the general challenges associated with optimizing the most suitable scaffold for DPC regeneration to develop "bio-mimetic" approaches that influence stem cell proliferation, differentiation, and angiogenesis. It is essential to comprehend the biology and physical features of the dentin-pulp complex with updated bionanotechnology to overcome the limitations of biomaterials to address the challenges in manufacturing the optimal scaffold. To date, current scaffolding models fail to regenerate a whole tooth. The success of regenerative dentistry relies on stem cells and scaffolds may shape the future of dental treatment.

Dental stem cell therapy (DSCT) is a promising domain in regenerative dentistry, yet the knowledge base, perceived barriers, and adoption readiness among p

Objective To map two decades of dental stem-cell (DSC) research across six subtypes and quantify translation-oriented signals (biomaterials/scaffolds, in vivo models, exosomes/extracellular vesicles, clinical-trial mentions). Design We searched Web of Science Core Collection (2000–2025), merged and de-duplicated records, and analyzed a deduplicated corpus (N = 13,327) using fractional counting for corpus-level maps. Annual outputs and subtype timelines were summarized. Conceptual structure was mapped with keyword co-occurrence (minimum term occurrence ≥ 8) and document co-citation (minimum co-citation ≥ 20) in VOSviewer (association-strength normalization). Translation tags were assigned via rule-based dictionaries aligned to community terminology and verified by manual screening; tags are treated as signals in titles/abstracts/keywords rather than outcomes. Inter-rater reliability for manual tagging was substantial (Cohen’s κ = 0.63, 95% CI 0.55–0.71; percent agreement 86% ) , based on a stratified dual-coded subset. Results The literature spans 1,462 journals and grows steadily after 2010, peaking in the early 2020s; outputs are concentrated in East Asia and North America. Co-occurrence mapping resolves four stable themes: pulp/dentin regeneration, periodontal regeneration, immunomodulation/exosomes, and pediatric/neuroregeneration. Co-citation analysis reveals a concordant four-cluster intellectual base anchored by early discovery papers and later biomaterials/differentiation work. Translation signals are most frequent for biomaterials/scaffolds and in vivo studies; exosomes/extracellular vesicles expand after 2015; clinical-trial mentions are present but comparatively rare. Conclusions This study provides a unified, deduplicated map of DSC research and a first estimate of translation-oriented signals that complement volume and topic trends. The results offer a current baseline for investigators and funders and a framework for tracking translation over time.