Objective: Noise and low quality of ECG signals acquired from Holter or wearable devices deteriorate the accuracy and robustness of R-peak detection algorithms. This paper presents a generic and robust system for R-peak detection in Holter ECG signals. While many proposed algorithms have successfully addressed the problem of ECG R-peak detection, there is still a notable gap in the performance of these detectors on such low-quality ECG records. Methods: In this study, a novel implementation of the 1D Convolutional Neural Network (CNN) is used integrated with a verification model to reduce the number of false alarms. This CNN architecture consists of an encoder block and a corresponding decoder block followed by a sample-wise classification layer to construct the 1D segmentation map of R-peaks from the input ECG signal. Once the proposed model has been trained, it can solely be used to detect R-peaks possibly in a single channel ECG data stream quickly and accurately, or alternatively, such a solution can be conveniently employed for real-time monitoring on a lightweight portable device. Results: The model is tested on two open-access ECG databases: The China Physiological Signal Challenge (2020) database (CPSC-DB) with more than one million beats, and the commonly used MIT-BIH Arrhythmia Database (MIT-DB). Experimental results demonstrate that the proposed systematic approach achieves 99.30% F1-score, 99.69% recall, and 98.91% precision in CPSC-DB, which is the best R-peak detection performance ever achieved. Results also demonstrate similar or better performance than most competing algorithms on MIT-DB with 99.83% F1-score, 99.85% recall, and 99.82% precision. Significance: Compared to all competing methods, the proposed approach can reduce the false-positives and false-negatives in Holter ECG signals by more than 54% and 82%, respectively. Conclusion: Finally, the simple and invariant nature of the parameters leads to a highly generic system and therefore applicable to any ECG dataset.

Objective: Despitethe proliferation of numerous deep learning methods proposed for generic ECG classification and arrhythmia detection, compact systems with the real-time ability and high accuracy for classifying patient-specific ECG are still few. Particularly, the scarcity of patient-specific data poses an ultimate challenge to any classifier. Recently, compact 1D Convolutional Neural Networks (CNNs) have achieved the state-of-the-art performance level for the accurate classification of ventricular and supraventricular ectopic beats. However, several studies have demonstrated the fact that the learning performance of the conventional CNNs is limited because they are homogenous networks with a basic (linear) neuron model. In order to address this deficiency and further boost the patient-specific ECG classification performance, in this study, we propose 1D Self-organized Operational Neural Networks (1D Self-ONNs). Methods: Due to its self-organization capability, Self-ONNs have the utmost advantage and superiority over conventional ONNs where the prior operator search within the operator set library to find the best possible set of operators is entirely avoided. Results: Under AAMI recommendations and with minimal common training data used, over the entire MIT-BIH dataset 1D Self-ONNs have achieved 98% and 99.04% average accuracies, 76.6% and 93.7% average F1 scores on supra-ventricular and ventricular ectopic beat (VEB) classifications, respectively, which is the highest performance level ever reported. Conclusion: As the first study where 1D Self-ONNs are ever proposed for a classification task, our results over the MIT-BIH arrhythmia benchmark database demonstrate that 1D Self-ONNs can surpass 1D CNNs with a significant margin while having a similar computational complexity.

Glaucoma leads to permanent vision disability by damaging the optical nerve that transmits visual images to the brain. The fact that glaucoma does not show any symptoms as it progresses and cannot be stopped at the later stages, makes it critical to be diagnosed in its early stages. Although various deep learning models have been applied for detecting glaucoma from digital fundus images, due to the scarcity of labeled data, their generalization performance was limited along with high computational complexity and special hardware requirements. In this study, compact Self-Organized Operational Neural Networks (Self-ONNs) are proposed for early detection of glaucoma in fundus images and their performance is compared against the conventional (deep) Convolutional Neural Networks (CNNs) over three benchmark datasets: ACRIMA, RIM-ONE, and ESOGU. The experimental results demonstrate that Self-ONNs not only achieve superior detection performance but can also significantly reduce the computational complexity making it a potentially suitable network model for biomedical datasets especially when the data is scarce.

Objective: ECG recordings often suffer from a set of artifacts with varying types, severities, and durations, and this makes an accurate diagnosis by machines or medical doctors difficult and unreliable. Numerous studies have proposed ECG denoising; however, they naturally fail to restore the actual ECG signal corrupted with such artifacts due to their simple and naive noise model. In this pilot study, we propose a novel approach for blind ECG restoration using cycle-consistent generative adversarial networks (Cycle-GANs) where the quality of the signal can be improved to a clinical level ECG regardless of the type and severity of the artifacts corrupting the signal. Methods: To further boost the restoration performance, we propose 1D operational Cycle-GANs with the generative neuron model. Results: The proposed approach has been evaluated extensively using one of the largest benchmark ECG datasets from the China Physiological Signal Challenge (CPSC-2020) with more than one million beats. Besides the quantitative and qualitative evaluations, a group of cardiologists performed medical evaluations to validate the quality and usability of the restored ECG, especially for an accurate arrhythmia diagnosis. Significance: As a pioneer study in ECG restoration, the corrupted ECG signals can be restored to clinical level quality. Conclusion: By means of the proposed ECG restoration, the ECG diagnosis accuracy and performance can significantly improve.

Preventive maintenance of modern electric rotating machinery (RM) is critical for ensuring reliable operation, preventing unpredicted breakdowns and avoiding costly repairs. Recently many studies investigated machine learning monitoring methods especially based on Deep Learning networks focusing mostly on detecting bearing faults; however, none of them addressed bearing fault severity classification for early fault diagnosis with high enough accuracy. 1D Convolutional Neural Networks (CNNs) have indeed achieved good performance for detecting RM bearing faults from raw vibration and current signals but did not classify fault severity. Furthermore, recent studies have demonstrated the limitation in terms of learning capability of conventional CNNs attributed to the basic underlying linear neuron model. Recently, Operational Neural Networks (ONNs) were proposed to enhance the learning capability of CNN by introducing non-linear neuron models and further heterogeneity in the network configuration. In this study, we propose 1D Self-organized ONNs (Self-ONNs) with generative neurons for bearing fault severity classification and providing continuous condition monitoring. Experimental results over the benchmark NSF/IMS bearing vibration dataset using both x- and y-axis vibration signals for inner race and rolling element faults demonstrate that the proposed 1D Self-ONNs achieve significant performance gap against the state-of-the-art (1D CNNs) with similar computational complexity.

Robust and real-time detection of faults has become an ultimate objective for predictive maintenance on rotating machinery. Vibration-based Deep Learning (DL) methodologies have become the de facto standard for bearing fault detection as they can produce state-of-the-art detection performances under certain conditions. Despite such particular focus on the vibration signal, the utilization of sound, on the other hand, has been widely neglected. As a result, no large-scale benchmark motor fault dataset exists with both sound and vibration data. The novel and significant contributions of this study can be summarized as follows. This study presents and publically shares the Qatar University Dual-Machine Bearing Fault Benchmark dataset (QU-DMBF), which encapsulates sound and vibration data from two different motors operating under 1080 working conditions. Then, we focus on the major limitations and drawbacks of vibration-based fault detection due to numerous installation and operational conditions. Finally, we propose the first DL approach for sound-based fault detection and perform comparative evaluations between the sound and vibration signals over the QU-DMBF dataset. A wide range of experimental results shows that the sound-based fault detection method is significantly more robust than its vibration-based counterpart, as it is entirely independent of the sensor location, cost-effective (requiring no sensor and sensor maintenance), and can achieve the same level of the best detection performance by its vibration-based counterpart. This study publicly shares the QU-DMBF dataset, the optimized source codes in PyTorch, and comparative evaluations with the research community.