Background/Objectives: Distal radius fractures are common upper extremity injuries requiring reliable outcome measures for accurate clinical assessment. This study aimed to validate the Croatian versions of the Disabilities of the Arm, Shoulder and Hand (DASH), Patient-Rated Wrist Evaluation (PRWE), and Mayo Wrist Score (MWS) in patients with distal radius fractures. Methods: DASH, PRWE, and MWS Croatian versions were evaluated in 128 patients using standardized translation, cultural adaptation, factor analysis, and internal consistency (Cronbach’s α). Results: PRWE-Cro and DASH-Cro demonstrated excellent validity and internal consistency (α > 0.95). QuickDASH-Cro showed high reliability and is recommended as a practical alternative. MWS was validated for the first time, showing good validity and acceptable internal consistency (α = 0.71). Conclusions: PRWE-Cro and DASH-Cro are validated, reliable instruments suitable for both clinical practice and research in Croatian-speaking populations while MWS can be used as a quick screening tool.